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PMID: 7045874 Published · ppublish English Journal Article

Mutagenicity of oxygen free radicals.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 79 ·No. 9 ·1982-05-00 ·Pages 2855-9

Moody CS, Hassan HM

Abstract

Paraquat (1,1'-dimethyl-4,4'-bipyridinium dichloride) was used as an intracellular generator of oxygen free radicals and was found to be highly mutagenic for Salmonella typhimurium. It caused both base-pair substitution and frameshift mutations. Paraquat was much more toxic and mutagenic in a simple nutritionally restricted medium than in a rich complex medium. The mutagenicity of paraquat was dependent upon the presence of a supply of both electrons and oxygen. Cells containing high levels of superoxide dismutase (superoxide:superoxide oxidoreductase, EC 1.15.1.1) were more resistant to the toxicity and the mutagenicity of paraquat than were cells containing normal levels of this enzyme. The mutagenicity of paraquat thus appears to be due to its ability to exacerbate the intracellular production of superoxide radicals.

MeSH Terms
Catalase/metabolism Free Radicals Mutagenicity Tests Mutagens Oxygen Paraquat/toxicity Salmonella typhimurium/drug effects Superoxide Dismutase/metabolism
Chemicals
Free Radicals Mutagens Catalase Superoxide Dismutase Paraquat Oxygen
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Moody C S
Hassan H M
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36 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.79.9.2855
Published
1982-05-00
Pages
2855-9
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC346305
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.79.9.2855 PMC Full Text View journal details
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