Home LiteratureArticle Details
PMID: 7048259 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Use of the 'Perceptron' algorithm to distinguish translational initiation sites in E. coli.

Nucleic acids research ·Vol. 10 ·No. 9 ·1982-05-11 ·Pages 2997-3011

Stormo GD, Schneider TD, Gold L, Ehrenfeucht A

Abstract

We have used a "Perceptron" algorithm to find a weighting function which distinguishes E. coli translational initiation sites from all other sites in a library of over 78,000 nucleotides of mRNA sequence. The "Perceptron" examined sequences as linear representations. The "Perceptron" is more successful at finding gene beginnings than our previous searches using "rules" (see previous paper). We note that the weighting function can find translational initiation sites within sequences that were not included in the training set.

MeSH Terms
Base Sequence Escherichia coli/genetics Mathematics Models, Genetic Peptide Chain Initiation, Translational RNA, Messenger/genetics
Chemicals
RNA, Messenger
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Stormo G D
Schneider T D
Gold L
Ehrenfeucht A
References (14)
14 references, click to expand
  1. Autoregulation and function of a repressor in bacteriophage lambda.
    Science. 1976 Oct 8;194(4261):156-61 PMID: 959843
  2. Protein cleavage during virus assembly: a novel specificity of assembly dependent cleavage in bacteriophage T4.
    Proc Natl Acad Sci U S A. 1976 Nov;73(11):4205-9 PMID: 1069310
  3. The genome of bacteriophage T4.
    Bacteriol Rev. 1976 Dec;40(4):847-68 PMID: 795415
  4. Temperature-sensitive mutation in the initiation codon of the rIIB gene of bacteriophage T4.
    Proc Natl Acad Sci U S A. 1979 Feb;76(2):700-4 PMID: 284393
  5. The nucleotide sequence of the cloned tufA gene of Escherichia coli.
    Gene. 1980 Dec;12(1-2):25-31 PMID: 7011903
  6. The nucleotide sequence of tufB and four nearby tRNA structural genes of Escherichia coli.
    Gene. 1980 Dec;12(1-2):33-9 PMID: 7011904
  7. Nucleotide sequence of the lexA gene of E. coli.
    Cell. 1981 Mar;23(3):689-97 PMID: 7013987
  8. Nucleotide sequence coding for the respiratory NADH dehydrogenase of Escherichia coli. UUG initiation codon.
    Eur J Biochem. 1981 May;116(1):165-70 PMID: 6265208
  9. Nucleotide sequence of the gene for ribosomal protein S20 and its flanking regions.
    J Biol Chem. 1981 Aug 10;256(15):8177-82 PMID: 6267039
  10. The nucleotide sequence of the cloned rpoD gene for the RNA polymerase sigma subunit from E coli K12.
    Nucleic Acids Res. 1981 Jun 25;9(12):2889-903 PMID: 6269063
  11. Translational initiation in prokaryotes.
    Annu Rev Microbiol. 1981;35:365-403 PMID: 6170248
  12. Nucleotide sequence of the lexA gene of Escherichia coli K-12.
    Nucleic Acids Res. 1981 Aug 25;9(16):4149-61 PMID: 6272195
  13. Nucleotide sequence from the genetic left end of bacteriophage T7 DNA to the beginning of gene 4.
    J Mol Biol. 1981 Jun 5;148(4):303-30 PMID: 7310871
  14. A role for mRNA secondary structure in the control of translation initiation.
    Nature. 1982 Feb 18;295(5850):616-8 PMID: 6799842
Article Info
Journal
Nucleic acids research
Abbr.
Nucleic Acids Res
ISSN
0305-1048
DOI
10.1093/nar/10.9.2997
Published
1982-05-11
Pages
2997-3011
Language
English
Region
England
NLM ID
0411011
PMCID
PMC320670
Subset
IM
Grants
NIGMS NIH HHS · GM28755 · United States
External Links
PubMed source DOI: 10.1093/nar/10.9.2997 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2