Susceptibility of Nocardia asteroides to various antibiotics, including newer beta-lactams, trimethoprim-sulfamethoxazole, amikacin, and N-formimidoyl thienamycin.

Antimicrobial agents and chemotherapy ·Vol. 21 ·No. 6 ·1982-06-00 ·Pages 1011-2

Gombert ME

Abstract

The susceptibility of 26 isolates of Nocardia asteroides to several antibiotics was determined by the agar dilution technique. Many currently available beta-lactam antibiotics were ineffective. Cefotaxime, cefmenoxime, and N-formimidoyl thienamycin were active against these strains, with 80% minimal inhibitory concentrations of 4, 4, and 2 micrograms/ml, respectively. Amikacin was the most effective agent tested.

MeSH Terms

Amikacin/pharmacology Anti-Bacterial Agents/pharmacology Drug Combinations/pharmacology Imipenem Microbial Sensitivity Tests Nocardia asteroides/drug effects Sulfamethoxazole/pharmacology Trimethoprim/pharmacology Trimethoprim, Sulfamethoxazole Drug Combination beta-Lactams/pharmacology

Chemicals

Anti-Bacterial Agents Drug Combinations beta-Lactams Imipenem Trimethoprim, Sulfamethoxazole Drug Combination Amikacin Trimethoprim Sulfamethoxazole

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Gombert M E

References (4)

4 references, click to expand

In vitro studies of the combined effect of ampicillin and sulfonamides on Nocardia asteroides and results of therapy in four patients.
Antimicrob Agents Chemother. 1972 Mar;1(3):215-20 PMID: 4558140
Nocardia asteroides; studies of its pathogenicity and drug sensitivities.
J Lab Clin Med. 1951 May;37(5):713-20 PMID: 14841414
In vitro susceptibility of Nocardia asteroides to amikacin.
Antimicrob Agents Chemother. 1978 Jan;13(1):128-9 PMID: 343712
Activity of minocycline against Nocardia asteroides: comparison with tetracycline in agar-dilution and standard disc-diffusion tests and with sulfadiazine in an experimental infection of mice.
J Lab Clin Med. 1973 May;81(5):787-93 PMID: 4572814

Article Info

Journal

Antimicrobial agents and chemotherapy

Abbr.

Antimicrob Agents Chemother

ISSN

0066-4804

DOI

10.1128/AAC.21.6.1011

Published

1982-06-00

Pages

1011-2

Language

English

Region

United States

NLM ID

0315061

PMCID

PMC182064

Subset

External Links

PubMed source DOI: 10.1128/AAC.21.6.1011 PMC Full Text View journal details

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Susceptibility of Nocardia asteroides to various antibiotics, including newer beta-lactams, trimethoprim-sulfamethoxazole, amikacin, and N-formimidoyl thienamycin.

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