Hepatic fibrosis in schistosomiasis: egg granulomas secrete fibroblast stimulating factor in vitro.

Science (New York, N.Y.) ·Vol. 202 ·No. 4366 ·1978-10-27 ·Pages 438-40

Wyler DJ, Wahl SM, Wahl LM

Abstract

Cytosol extracts and culture supernatants of isolated egg granulomas obtained from livers of mice with Schistosoma mansoni infection stimulated fibroblasts to incorporate tritiated thymidine and to proliferate in vitro. This finding suggests that hepatic granulomas may play a role in regulating hepatic fibrosis in Schistosoma mansoni infections.

MeSH Terms

Animals Cell Division Fibroblasts/pathology Granuloma/complications,etiology,metabolism Growth Substances/metabolism Inflammation/physiopathology Liver Cirrhosis/etiology Mice Schistosoma mansoni Schistosomiasis/complications,pathology,physiopathology

Chemicals

Growth Substances

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Wyler D J

Wahl S M

Wahl L M

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.705337

Published

1978-10-27

Pages

438-40

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.705337 View journal details

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Hepatic fibrosis in schistosomiasis: egg granulomas secrete fibroblast stimulating factor in vitro.

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