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PMID: 7053569 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Is the acetylcholine receptor a rabies virus receptor?

Science (New York, N.Y.) ·Vol. 215 ·No. 4529 ·1982-01-08 ·Pages 182-4

Lentz TL, Burrage TG, Smith AL, Crick J, Tignor GH

Abstract

Rabies virus was found on mouse diaphragms and on cultured chick myotubes in a distribution coinciding with that of the acetylcholine receptor. Treatment of the myotubes with alpha-bungarotoxin and d-tubocurarine before the addition of the virus reduced the number of myotubes that became infected with rabies virus. These findings together suggest that acetylcholine receptors may serve as receptors for rabies virus. The binding of virus to acetylcholine receptors, which are present in high density at the neuromuscular junction, would provide a mechanism whereby the virus could be locally concentrated at sites in proximity to peripheral nerves facilitating subsequent uptake and transfer to the central nervous system.

MeSH Terms
Acetylcholine/metabolism Acetylcholinesterase/metabolism Animals Binding, Competitive Bungarotoxins/metabolism Cells, Cultured Chick Embryo Diaphragm Mice Microscopy, Electron Neuromuscular Junction/metabolism Rabies virus/metabolism Receptors, Cholinergic/metabolism Receptors, Virus/metabolism Tubocurarine/metabolism
Chemicals
Bungarotoxins Receptors, Cholinergic Receptors, Virus Acetylcholinesterase Acetylcholine Tubocurarine
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Lentz T L
Burrage T G
Smith A L
Crick J
Tignor G H
Article Info
Journal
Science (New York, N.Y.)
Abbr.
Science
ISSN
0036-8075
Published
1982-01-08
Pages
182-4
Language
English
Region
United States
NLM ID
0404511
Subset
IM
Grants
NIAID NIH HHS · AI 11132 · United States
NIAID NIH HHS · AI 12541 · United States
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