Effect of the active tumor promoter, 12-O-tetradecanoylphorbol-13-acetate on hair follicular growth and development of hair anlage tumors in the mouse skin: a comparison with human adnexal lesions.

Journal of cancer research and clinical oncology ·Vol. 102 ·No. 3 ·1982-00-00 ·Pages 245-52

Bhisey RA, Iyengar B, Sirsat SM

Abstract

Effect of the active tumor promoter, TPA, on the induction of hair follicular growth and possible neoplasia was studied histologically in normal nd precancerous mouse skin. Biweekly application of TPA resulted in nevoid proliferation of hair follicles, decreased the latent period of tumor induction, and increased the number of carcinomas of hair follicular origin in mice pretreated with MCA. The experimental tumor induction data was compared with human adnexal tumors of hair follicular origin. Similar types of animal and human lesions could be attributed to the promoter effect alone or to the dual influence of a carcinogen and promoter.

MeSH Terms

Animals Cocarcinogenesis Epidermis/drug effects,pathology Female Hair/drug effects,pathology Humans Hyperplasia Methylcholanthrene Mice Phorbols/pharmacology Precancerous Conditions/chemically induced,pathology Skin/drug effects,pathology Skin Neoplasms/chemically induced,pathology Tetradecanoylphorbol Acetate/pharmacology

Chemicals

Phorbols Methylcholanthrene Tetradecanoylphorbol Acetate

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Bhisey R A

Iyengar B

Sirsat S M

References (9)

9 references, click to expand

Tumor-promoting activity of phorbol and four diesters of phorbol in mouse skin.
Cancer Res. 1971 Aug;31(8):1074-9 PMID: 5095975
Early effects of 12-O-tetradecanoyl-phorbol-13-acetate on the incorporation of tritiated precursor into DNA and the thickness of the interfollicular epidermis, and their relation to tumor promotion in mouse skin.
Cancer Res. 1972 Jul;32(7):1562-8 PMID: 5030581
The role of the hair follicle in the origin and evolution of some cutaneous neoplasms of man and experimental animals.
Cancer. 1961 Jul-Aug;14:801-16 PMID: 13704883
An experimental analysis of the hair cycle effect in mouse skin carcinogenesis.
Br J Cancer. 1958 Sep;12(3):402-13 PMID: 13596493
Selective promoting activity of phorbol myristate acetate in experimental skin carcinogenesis.
Br J Cancer. 1976 Dec;34(6):661-5 PMID: 1008993
Ultrastructural, histological, and biochemical alterations produced by 12-O-tetradecanoyl-phorbol-13-acetate on mouse epidermis and their relevance to skin tumor promotion.
Cancer Res. 1973 Feb;33(2):269-86 PMID: 4347466
Induction of the formation of new hair follicles in mouse tail epidermis by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate.
Cancer Res. 1977 Nov;37(11):4195-201 PMID: 409492
The sensitivity of the skin of hairless mice to chemical carcinogenesis.
Cancer Res. 1976 Apr;36(4):1238-41 PMID: 1260754
Action of methylcholanthrene on certain scars of the skin in mice.
Cancer Res. 1946 Apr;6:183-8 PMID: 21018721

Article Info

Journal

Journal of cancer research and clinical oncology

Abbr.

J Cancer Res Clin Oncol

ISSN

0171-5216

DOI

10.1007/BF00411344

Published

1982-00-00

Pages

245-52

Language

English

Region

Germany

NLM ID

7902060

Subset

External Links

PubMed source DOI: 10.1007/BF00411344 View journal details

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Effect of the active tumor promoter, 12-O-tetradecanoylphorbol-13-acetate on hair follicular growth and development of hair anlage tumors in the mouse skin: a comparison with human adnexal lesions.

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