Home LiteratureArticle Details
PMID: 7065119 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Hydrodynamic injury of the endothelium in acute aortic stenosis.

The American journal of pathology ·Vol. 106 ·No. 3 ·1982-03-00 ·Pages 394-408

Joris I, Zand T, Majno G

Abstract

The acute effects of increased shear stress on the endothelium were studied by reducing the lumen of the rat aorta to 20-25% of normal by means of metal clips. Intimal damage in the stenotic area was assessed by light microscopy after perfusion with AgNo3 and study of the endothelium en face. Most of the endothelium was lost within 3 minutes; the extent of the damage was not increased after 1 hour. Electron-microscopic examination showed that some endothelial cells became permeable to tracers (thorium dioxide and horseradish peroxidase); platelets adhered to the exposed internal elastic membrane. Focal endothelial changes were represented by myelin figures of various kinds arising from the luminal surface and by "cellular ulcers," superficial erosions of the endothelial cells accompanied by localized cytoplasmic changes. These "ulcers" occurred more frequently over the nucleus and near junctions; they have not been described in other forms of arterial injury.

MeSH Terms
Animals Aorta, Abdominal/pathology,ultrastructure Aortic Valve Stenosis/pathology,physiopathology Blood Pressure Contrast Media/administration & dosage Endothelium/pathology,ultrastructure Hemodynamics Horseradish Peroxidase/administration & dosage Male Microscopy, Electron Rats Rats, Inbred Strains Silver Nitrate/administration & dosage Stress, Mechanical
Chemicals
Contrast Media Silver Nitrate Horseradish Peroxidase
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Joris I
Zand T
Majno G
References (27)
27 references, click to expand
  1. Acute vascular endothelial changes associated with increased blood velocity gradients.
    Circ Res. 1968 Feb;22(2):165-97 PMID: 5639037
  2. An extension of item analysis procedures to the case of polychotomous response.
    Psychometrika. 1968 Sep;33(3):259-66 PMID: 5243963
  3. Certain histological and chemical responses of the vascular interface to acutely induced mechanical stress in the aorta of the dog.
    Circ Res. 1969 Jan;24(1):93-108 PMID: 5763742
  4. Graded endothelial injury of the rabbit aorta. With special reference to platelet deposition.
    Arch Pathol. 1970 Sep;90(3):222-9 PMID: 5451889
  5. Atheroma and arterial wall shear. Observation, correlation and proposal of a shear dependent mass transfer mechanism for atherogenesis.
    Proc R Soc Lond B Biol Sci. 1971 Feb 16;177(1046):109-59 PMID: 4396262
  6. Small intestinal absorption of horseradish peroxidase. A cytochemical study.
    Lab Invest. 1971 Jul;25(1):42-8 PMID: 4326524
  7. Endothelial nuclear patterns in the canine arterial tree with particular reference to hemodynamic events.
    Circ Res. 1972 Jan;30(1):23-33 PMID: 5007525
  8. Venous endothelium of experimental arteriovenous fistulas in rabbits.
    Circ Res. 1972 Oct;31(4):546-56 PMID: 4116427
  9. Mechanical stresses on vessels and the non-uniform distribution of atherosclerosis.
    Med Clin North Am. 1973 Jan;57(1):63-77 PMID: 4569833
  10. Blood flow disturbance and endothelial cell injury in preatherosclerotic swine.
    Lab Invest. 1973 Aug;29(2):134-49 PMID: 4724846
  11. Haemodynamic production of lipid deposition, intimal teats, mural dissection and thrombosis in the blood vessel wall.
    Proc R Soc Lond B Biol Sci. 1974 Feb 12;185(1080):357-73 PMID: 4149928
  12. The ultrastructure of the anastomosed vein of experimental arteriovenous fistulae in sheep.
    Am J Pathol. 1974 Aug;76(2):377-400 PMID: 4843387
  13. Restitution of aortic wall after sustained necrotizing transmural ligation injury. Role of blood cells and artery cells.
    Am J Pathol. 1975 Apr;79(1):7-30 PMID: 1124799
  14. Disturbance of blood flow as a factor of thrombus formation.
    Thromb Res. 1976 May;8(2 suppl):375-80 PMID: 936090
  15. The evolution of early fibromuscular lesions hemodynamically induced in the dog renal artery. I. Light and transmission electron microscopy.
    Circ Res. 1976 Dec;39(6):809-27 PMID: 1000775
  16. Sequential uptake of horseradish peroxidase by lymphoid follicle epithelium of Peyer's patches in the normal unobstructed mouse intestine: an ultrastructural study.
    Gastroenterology. 1977 Mar;72(3):440-51 PMID: 832793
  17. Scanning electron microscopy of arteries. The morphology of aortic endothelium in haemodynamically stressed areas associated with branches.
    Atherosclerosis. 1977 Feb;26(2):181-94 PMID: 836354
  18. Cell-to-cell herniae in the arterial wall. I. The pathogenesis of vacuoles in the normal media.
    Am J Pathol. 1977 May;87(2):375-98 PMID: 557903
  19. Focal "spontaneous" alterations and loss of endothelial cells in rabbit aorta.
    Acta Pathol Microbiol Scand A. 1978 Jan;86(1):1-13 PMID: 636884
  20. Endothelial cell damage and thrombosis following partial coronary arterial constriction: relevance to the pathogenesis of myocardial infarction.
    Isr J Med Sci. 1978 Mar;14(3):384-8 PMID: 640824
  21. Horseradish peroxidase as a label of injured cells.
    Histochem J. 1979 May;11(3):337-44 PMID: 457441
  22. Cellular pathology of the rat aorta. Pseudo-vacuoles and myo-endothelial herniae.
    Virchows Arch A Pathol Anat Histol. 1979 Jul 31;383(2):135-48 PMID: 157618
  23. The effect of local blood flow patterns on endothelial cell morphology.
    Exp Mol Pathol. 1980 Jun;32(3):276-89 PMID: 7379981
  24. Impaired sarcolemmal membrane permeability in reperfused ischemic myocardium. Ultrastructural tracer study.
    Virchows Arch A Pathol Anat Histol. 1980;388(1):69-76 PMID: 7467122
  25. Endothelial changes induced by arterial spasm.
    Am J Pathol. 1981 Mar;102(3):346-58 PMID: 7212018
  26. Alteration of endothelial cell surface morphology after experimental aortic coarctation.
    Artery. 1980;8(3):267-74 PMID: 7213036
  27. Observations on localization of arterial plaques.
    Circ Res. 1962 Jul;11:63-73 PMID: 13909682
Article Info
Journal
The American journal of pathology
Abbr.
Am J Pathol
ISSN
0002-9440
Published
1982-03-00
Pages
394-408
Language
English
Region
United States
NLM ID
0370502
PMCID
PMC1916227
Subset
IM
Grants
NHLBI NIH HHS · HL-16952 · United States
NHLBI NIH HHS · HL-25973 · United States
External Links
PubMed source PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2