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PMID: 7066091 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Lysis gene expression of RNA phage MS2 depends on a frameshift during translation of the overlapping coat protein gene.

Nature ·Vol. 295 ·No. 5844 ·1982-01-07 ·Pages 35-41

Kastelein RA, Remaut E, Fiers W, van Duin J

Abstract

Translation of the lysis cistron of MS2 RNA requires a frameshift of ribosomes reading the upstream coat protein mRNA. The out-of-phase fraction of ribosomes terminates at either one of two nonsense codons just preceding the lysis cistron. Termination is followed by initiation at the start codon of the lysis protein message.

MeSH Terms

Base Sequence Coliphages/genetics Genes, Viral Lysogeny Nucleic Acid Conformation Plasmids Protein Biosynthesis RNA Viruses/genetics RNA, Messenger/genetics Species Specificity Transcription, Genetic Viral Proteins/genetics

Chemicals

RNA, Messenger Viral Proteins

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Kastelein R A

Remaut E

Fiers W

van Duin J

Article Info

Journal

Nature

Abbr.

Nature

ISSN

0028-0836

DOI

10.1038/295035a0

Published

1982-01-07

Pages

35-41

Language

English

Region

England

NLM ID

0410462

Subset

Databases

GENBANK

J02467, V00642

External Links

PubMed source DOI: 10.1038/295035a0 View journal details

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Lysis gene expression of RNA phage MS2 depends on a frameshift during translation of the overlapping coat protein gene.

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