Tritiated imipramine binding sites are decreased in the frontal cortex of suicides.

Science (New York, N.Y.) ·Vol. 216 ·No. 4552 ·1982-06-18 ·Pages 1337-9

Stanley M, Virgilio J, Gershon S

Abstract

Binding characteristics of tritiated imipramine were determined in the frontal cortex of suicides and well-matched controls. Maximal binding was significantly lower in brains from the suicides. This finding is consistent with reports of decreased tritiated imipramine binding in the platelets of patients diagnosed as having a major affective disorder.

MeSH Terms

Adolescent Adult Carrier Proteins Cerebral Cortex/metabolism Humans Imipramine/metabolism Kinetics Middle Aged Receptors, Drug/metabolism Reference Values Suicide Tritium

Chemicals

Carrier Proteins Receptors, Drug imipramine receptor Tritium Imipramine

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Stanley M

Virgilio J

Gershon S

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.7079769

Published

1982-06-18

Pages

1337-9

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.7079769 View journal details

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Tritiated imipramine binding sites are decreased in the frontal cortex of suicides.

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