Synthesis of N7-hydroxyethylguanine and O6-hydroxyethylguanine. Markers for the reaction of ethylene oxide (EO) with DNA.

Mutation research ·Vol. 103 ·No. 3-6 ·1982-03-00 ·Pages 257-61

Ashby J, Paton D, Styles JA, Greatbanks D, Wright B

Abstract

O6-Hydroxyethylguanine has been synthesized by reaction of mono-sodium glycolate with 6-chloroguanine. The crystalline product has been characterized using a variety of analytical techniques and compared with a sample of the corresponding N7-hydroxyethyl derivative. These 2 chemicals may prove useful as standards when studying the reaction of ethylene oxide (EO) with DNA.

MeSH Terms

Chemical Phenomena Chemistry DNA/metabolism Ethylene Oxide/pharmacology Guanine/analogs & derivatives,analysis,chemical synthesis Magnetic Resonance Spectroscopy Mass Spectrometry Mutagens/pharmacology

Chemicals

Mutagens N(7)-hydroxyethylguanine Guanine 6-hydroxyethylguanine DNA Ethylene Oxide

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Ashby J

Paton D

Styles J A

Greatbanks D

Wright B

Article Info

Journal

Mutation research

Abbr.

Mutat Res

ISSN

0027-5107

DOI

10.1016/0165-7992(82)90051-3

Published

1982-03-00

Pages

257-61

Language

English

Region

Netherlands

NLM ID

0400763

Subset

External Links

PubMed source DOI: 10.1016/0165-7992(82)90051-3 View journal details

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Synthesis of N7-hydroxyethylguanine and O6-hydroxyethylguanine. Markers for the reaction of ethylene oxide (EO) with DNA.

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