Magnetic relaxation analysis of dynamic processes in macromolecules in the pico- to microsecond range.

Biophysical journal ·Vol. 24 ·No. 1 ·1978-10-00 ·Pages 103-17

King R, Maas R, Gassner M, Nanda RK, Conover WW

Abstract

A formalism based on the theory of Markov processes and suitable for the analysis of multiple internal motions in macromolecules is presented. Computer calculations of specific motional models for (13)C nuclear magnetic resonance (NMR) relaxation, treated as special cases of the proposed formalism, demonstrate the potential of this approach for discriminating between different motional models on the basis of NMR relaxation data.

MeSH Terms

Macromolecular Substances Magnetic Resonance Spectroscopy Markov Chains Models, Theoretical Time Factors

Chemicals

Macromolecular Substances

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

King R

Maas R

Gassner M

Nanda R K

Conover W W

References (5)

5 references, click to expand

Conformational studies on angiotensin-II. Least-squares fit of carcon-13 nuclear magnetic resonance relaxation times to extended and folded conformations.
J Mol Biol. 1977 Jul 15;113(4):697-710 PMID: 894715
Nuclear magnetic resonance studies of sperm whale myoglobin specifically enriched with 13C in the methionine methyl groups.
J Biol Chem. 1976 Dec 10;251(23):7452-60 PMID: 12165
Studies of individual carbon sites of proteins in solution by natural abundance carbon 13 nuclear magnetic resonance spectroscopy. Relaxation behavior.
J Biol Chem. 1975 Aug 25;250(16):6368-80 PMID: 169239
Fluorotyrosine alkaline phosphatase: internal mobility of individual tyrosines and the role of chemical shift anisotropy as a 19F nuclear spin relaxation mechanism in proteins.
J Mol Biol. 1975 Oct 15;98(1):121-53 PMID: 1195374
13C Magnetic resonance evidence for anisotropic molecular motion in collagen fibrils.
J Mol Biol. 1976 Jun 14;104(1):315-21 PMID: 957438

Article Info

Journal

Biophysical journal

Abbr.

Biophys J

ISSN

0006-3495

DOI

10.1016/S0006-3495(78)85350-8

Published

1978-10-00

Pages

103-17

Language

English

Region

United States

NLM ID

0370626

PMCID

PMC1473880

Subset

External Links

PubMed source DOI: 10.1016/S0006-3495(78)85350-8 PMC Full Text View journal details

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Magnetic relaxation analysis of dynamic processes in macromolecules in the pico- to microsecond range.

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