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PMID: 7088189 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

The N-terminal arms of lambda repressor wrap around the operator DNA.

Nature ·Vol. 298 ·No. 5873 ·1982-07-29 ·Pages 441-3

Pabo CO, Krovatin W, Jeffrey A, Sauer RT

Abstract

From differences in the ability of fragments of the lambda repressor to protect operator bases from chemical modification we suggest that the first few N-terminal residues of the lambda repressor form an extended arm that reaches around the back of the DNA helix when repressor binds to the operator.

MeSH Terms

Amino Acid Sequence Base Sequence DNA, Bacterial/metabolism DNA-Binding Proteins Guanine/metabolism Methylation Models, Genetic Operon Peptide Fragments/analysis,metabolism Repressor Proteins/metabolism Transcription Factors/metabolism Trypsin/pharmacology Viral Proteins Viral Regulatory and Accessory Proteins

Chemicals

DNA, Bacterial DNA-Binding Proteins Peptide Fragments Repressor Proteins Transcription Factors Viral Proteins Viral Regulatory and Accessory Proteins phage repressor proteins Guanine Trypsin

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Pabo C O

Krovatin W

Jeffrey A

Sauer R T

Article Info

Journal

Nature

Abbr.

Nature

ISSN

0028-0836

DOI

10.1038/298441a0

Published

1982-07-29

Pages

441-3

Language

English

Region

England

NLM ID

0410462

Subset

Grants

NIAID NIH HHS · AI-16892 · United States

NIGMS NIH HHS · GM-22526 · United States

External Links

PubMed source DOI: 10.1038/298441a0 View journal details

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The N-terminal arms of lambda repressor wrap around the operator DNA.

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