Caffeine antagonizes diazepam effects in man.

Medical biology ·Vol. 60 ·No. 2 ·1982-04-00 ·Pages 121-3

Mattila MJ, Palva E, Savolainen K

Abstract

In a double-blind, placebo-controlled study on parallel groups of medical students diazepam 10 mg impaired cognitive skills and caused muscle relaxation. A 250 mg dose of caffeine given in decaffeinated coffee counteracted these better than a 500 mg dose. Subjectively, diazepam exerted a calming effect which was counteracted by caffeine at either at either dose levels.

MeSH Terms

Adult Caffeine/pharmacology Diazepam/antagonists & inhibitors Dose-Response Relationship, Drug Double-Blind Method Female Flicker Fusion/drug effects Humans Male Mental Processes/drug effects Muscle Contraction/drug effects Muscle Relaxation/drug effects Placebos Temperament/drug effects

Chemicals

Placebos Caffeine Diazepam

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Mattila M J

Palva E

Savolainen K

Article Info

Journal

Medical biology

Abbr.

Med Biol

ISSN

0302-2137

Published

1982-04-00

Pages

121-3

Language

English

Region

Finland

NLM ID

0417300

Subset

External Links

PubMed source

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Caffeine antagonizes diazepam effects in man.

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