Drug resistance studies with topical antiseptics.

Journal of pharmaceutical sciences ·Vol. 67 ·No. 11 ·1978-11-00 ·Pages 1629-31

Prince HN, Nonemaker WS, Norgard RC, Prince DL

Abstract

Species of Proteus, Serratia, and Pseudomonas became resistant to chlorhexidine after five to eight transfers in vitro. Cross-resistance to benzalkonium chloride also was detected. Resistance to povidone-iodine was not encountered. Chlorhexidine resistance was stable after drug-free transfers of Serratia and Pseudomonas but was transitory for Proteus.

MeSH Terms

Anti-Infective Agents, Local/pharmacology Bacteria/drug effects Benzalkonium Compounds/pharmacology Chlorhexidine/pharmacology Drug Resistance, Microbial Povidone-Iodine/pharmacology

Chemicals

Anti-Infective Agents, Local Benzalkonium Compounds Povidone-Iodine Chlorhexidine

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Prince H N

Nonemaker W S

Norgard R C

Prince D L

Article Info

Journal

Journal of pharmaceutical sciences

Abbr.

J Pharm Sci

ISSN

0022-3549

DOI

10.1002/jps.2600671134

Published

1978-11-00

Pages

1629-31

Language

English

Region

United States

NLM ID

2985195R

Subset

External Links

PubMed source DOI: 10.1002/jps.2600671134 View journal details

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