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PMID: 7143579 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Newcastle disease virus stimulates the cellular accumulation of stress (heat shock) mRNAs and proteins.

Journal of virology ·Vol. 44 ·No. 2 ·1982-11-00 ·Pages 703-7

Collins PL, Hightower LE

Abstract

A biological agent, Newcastle disease virus, stimulated the synthesis of stress proteins in cultured chicken embryo cells. Previously, only physical and chemical agents were known to induce these proteins. The levels of translatable stress mRNAs were elevated in cells infected with avirulent or virulent strains; however, stress protein synthesis was stimulated strongly only in cells infected by avirulent strains. As did several other paramyxoviruses, avirulent strains of Newcastle disease virus stimulated the synthesis of glucose-regulated proteins as well as stress proteins. Possible stimuli of the synthesis of these two sets of proteins in paramyxovirus-infected cells are considered.

MeSH Terms
Animals Cells, Cultured Chick Embryo HSP70 Heat-Shock Proteins Heat-Shock Proteins Hot Temperature Membrane Proteins/biosynthesis Newcastle disease virus/pathogenicity,physiology Protein Biosynthesis RNA, Messenger/biosynthesis RNA, Viral/metabolism
Chemicals
HSP70 Heat-Shock Proteins Heat-Shock Proteins Membrane Proteins RNA, Messenger RNA, Viral glucose-regulated proteins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Collins P L
Hightower L E
References (28)
28 references, click to expand
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.44.2.703-707.1982
Published
1982-11-00
Pages
703-7
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC256315
Subset
IM
Grants
NCI NIH HHS · CA 14733 · United States
NHLBI NIH HHS · HL 23588 · United States
External Links
PubMed source DOI: 10.1128/JVI.44.2.703-707.1982 PMC Full Text View journal details
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