Home LiteratureArticle Details
PMID: 7170063 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Developmental changes in mouse brain polyamine metabolism.

Neurochemical research ·Vol. 7 ·No. 12 ·1982-12-00 ·Pages 1477-85

Laitinen SI, Laitinen PH, Hietala OA, Pajunen AE, Piha RS

Abstract

Mouse brain ornithine decarboxylase (ODC) activity is high at the time of birth, whereas S-adenosyl-L-methionine decarboxylase (SAM-DC) activity is low. ODC activity, and putrescine, spermidine and spermine concentrations decline rapidly during postnatal development to the low level characteristic of mature brains, while SAM-DC activity behaves in the opposite manner. The fluctuations in mouse brain polyamine metabolism are in accord with those found in the rat. The apparent Km values of ODC and SAM-DC for their substrates decline parallel with the decrease of substrate and product concentrations during ontogeny suggesting substrate and/or product dependent regulation of polyamine synthesis in the developing brain.

MeSH Terms
Adenosylmethionine Decarboxylase/metabolism Aging Animals Brain/growth & development,metabolism Carboxy-Lyases/metabolism Kinetics Mice Mice, Inbred Strains Ornithine Decarboxylase/metabolism Polyamines/metabolism Putrescine/metabolism Spermidine/metabolism Spermine/metabolism
Chemicals
Polyamines Spermine Carboxy-Lyases Ornithine Decarboxylase Adenosylmethionine Decarboxylase Spermidine Putrescine
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Laitinen S I
Laitinen P H
Hietala O A
Pajunen A E
Piha R S
References (27)
27 references, click to expand
  1. Changes in cadaverine and putrescine metabolism in the mouse kidney induced to growth by an anabolic steroid.
    Acta Physiol Scand. 1982 Feb;114(2):225-33 PMID: 7136756
  2. On the purification of L-ornithine decarboxylase from rat prostate and effects of thiol compounds on the enzyme.
    J Biol Chem. 1971 Mar 25;246(6):1725-32 PMID: 5547701
  3. Polyamines in rapid growth and cancer.
    Biochim Biophys Acta. 1978 Apr 6;473(3-4):241-93 PMID: 350276
  4. Tissue distribution of S-adenosylmethionine and S-adenosylhomocysteine in the rat. Effect of age, sex and methionine administration on the metabolism of S-adenosylmethionine, S-adenosylhomocysteine and polyamines.
    Biochem J. 1977 Sep 15;166(3):521-9 PMID: 597242
  5. The effect of DL-allylglycine on polyamine and GABA metabolism in mouse brain.
    J Neurochem. 1979 May;32(5):1401-8 PMID: 438812
  6. Perinatal changes in the free amino acid pool of the brain in mice.
    Brain Res. 1973 May 30;55(1):238-41 PMID: 4736548
  7. Regulation of ornithine decarboxylase activity in the developing heart of euthyroid or hyperthyroid rats.
    Mol Pharmacol. 1980 Sep;18(2):247-52 PMID: 6158669
  8. Histamine and spermidine content in brain during development.
    Science. 1969 Dec 5;166(3910):1301-3 PMID: 5388977
  9. Polyamines: developmental alterations in regional disposition and metabolism in rat brain.
    J Neurochem. 1973 May;20(5):1443-52 PMID: 4716836
  10. Regulation of rat heart ornithine decarboxylase: change in affinity for ornithine evoked by neuronal, hormonal, and ontogenetic stimuli.
    Mol Pharmacol. 1979 Sep;16(2):504-12 PMID: 229401
  11. Physiology of the natural polyamines putrescine, spermidine and spermine.
    Med Biol. 1975 Jun;53(3):121-47 PMID: 169440
  12. Amine synthesis in rapidly growing tissues: ornithine decarboxylase activity in regenerating rat liver, chick embryo, and various tumors.
    Proc Natl Acad Sci U S A. 1968 Aug;60(4):1420-7 PMID: 4299947
  13. Determination of polyamines in urine.
    Clin Chim Acta. 1973 Nov 23;49(1):65-72 PMID: 4764340
  14. Pyridoxal 5'-phosphate and the regulation of ornithine decarboxylase activity and stability.
    Eur J Biochem. 1976 Aug 1;67(1):303-14 PMID: 964243
  15. Dissociation of putrescine-activated decarboxylation of S-adenosyl-L-methionine from the enzymic synthesis of spermidine and spermine by purified prostatic enzyme preparations.
    Biochem Biophys Res Commun. 1971 Jan 22;42(2):222-9 PMID: 5545514
  16. Use of the dansyl reaction in biochemical analysis.
    Methods Biochem Anal. 1970;18:259-337 PMID: 4913442
  17. Biochemical aspects of cardiac muscle differentiation. Possible control of deoxyribonucleic acid synthesis and cell differentiation by adrenergic innervation and cyclic adenosine 3':5'-monophosphate.
    J Biol Chem. 1976 Oct 10;251(19):6082-9 PMID: 184091
  18. Detection of multiple forms of rat liver ornithine decarboxylase.
    J Biol Chem. 1977 May 10;252(9):2860-5 PMID: 16004
  19. Biosynthesis of putrescine in the prostate gland of the rat.
    Biochem J. 1968 Jul;108(4):533-9 PMID: 5667265
  20. Stimulation of L-ornithine and S-adenosyl-L-methionine decarboxylases by beta-(p-chlorophenyl)-gamma-aminobutyric acid in mouse tissues.
    Acta Chem Scand B. 1978;32(5):322-6 PMID: 685624
  21. Interrelations between polyamines and nucleic acids: changes of polyamine and nucleic acid concentrations in the developing rat brain.
    J Neurochem. 1975 Jan;24(1):5-13 PMID: 1110367
  22. Biochemical aspects of cardiac muscle differentiation. Deoxyribonucleic acid synthesis and nuclear and cytoplasmic deoxyribonucleic acid polymerase activity.
    J Biol Chem. 1975 May 10;250(9):3229-35 PMID: 235544
  23. Adenosylmethionine decarboxylase in developing rat brain.
    J Neurochem. 1973 May;20(5):1373-85 PMID: 4716831
  24. Ornithine decarboxylase activity in developing rat brain.
    J Neurochem. 1972 Jun;19(6):1471-81 PMID: 5035297
  25. Protein measurement with the Folin phenol reagent.
    J Biol Chem. 1951 Nov;193(1):265-75 PMID: 14907713
  26. Effect of maternal deprivation on polyamine metabolism in preweanling rat brain and heart.
    Life Sci. 1977 Sep 15;21(6):877-84 PMID: 916804
  27. Physical and kinetic distinction of two ornithine decarboxylase forms in Physarum.
    Biochim Biophys Acta. 1977 Aug 11;483(2):425-34 PMID: 560866
Article Info
Journal
Neurochemical research
Abbr.
Neurochem Res
ISSN
0364-3190
DOI
10.1007/BF00965090
Published
1982-12-00
Pages
1477-85
Language
English
Region
United States
NLM ID
7613461
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00965090 View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2