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PMID: 71736 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Key antigenic determinants in regulation of the immune response.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 74 ·No. 9 ·1977-09-00 ·Pages 3984-7

Turkin D, Sercarz EE

Abstract

The immune response to beta-galactosidase (beta-D-galactoside galactohydrolase; EC 3.2.1.23)is characterized by a wave of early help followed by a wave of suppression to a subsequent in vitro challenge with galactosidase-fluorescein. A cyanogen bromide peptide of beta-galactosidase, CB2, mimics the suppression seen with the enzyme. It is time dependent, carrier specific, and anti-theta sensitive; however, this suppression is not preceded by a wave of help. It is possible that CB2 cannot stimulate helpers, and is only able to activate suppressor cells. These data indicate that one small region of an antigen, capable of activating suppressors, can nullify the positive effect induced in helper T cells reactive with other epitopes on beta-galactosidase. Key determinants on macromolecules may in this way be influential in regulating the immune response to the entire antigen molecule.

MeSH Terms
Animals Antibody Formation Epitopes Galactosidases/immunology Genes, MHC Class II Mice/immunology T-Lymphocytes/immunology beta-Galactosidase/immunology
Chemicals
Epitopes Galactosidases beta-Galactosidase
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Turkin D
Sercarz E E
References (20)
20 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.74.9.3984
Published
1977-09-00
Pages
3984-7
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC431811
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.74.9.3984 PMC Full Text View journal details
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