Home LiteratureArticle Details
PMID: 7175747 Published · ppublish English Journal Article

Metabolism and transport of strontium in giant axons of Loligo.

The Journal of physiology ·Vol. 330 ·1982-09-00 ·Pages 373-92

Baker PF, Singh R

Abstract

1. The strontium content of squid axons averages 2.9 mumol kg-1 axoplasm and squid blood contains 75 mumol Sr l-1. The bulk of the Sr inside axons is bound, possibly within mitochondria. Sr seems to be handled by squid axons in an essentially similar manner to Ca. 2. Sr uptake is increased by electrical activity, by lowering external Na, by depolarization with K and by poisoning with cyanide or FCCP. Uptake is unaffected by ouabain. 3. Sr efflux has a Q10 of 2.2. Efflux can be divided operationally into three components: one dependent on external Ca (or Sr), one dependent on external Na and a residual component that can be inhibited by external lanthanum or internal vanadate. 4. Poisoning an axon with cyanide or FCCP results in a large increase in Sr efflux which can be divided operationally into two components: one dependent on external Ca (or Sr) and one dependent on external Na.

MeSH Terms
Animals Axons/drug effects,metabolism Biological Transport, Active Calcium/metabolism Cyanides/pharmacology Decapodiformes Electric Stimulation Hydrogen-Ion Concentration Sodium/metabolism Strontium/metabolism Temperature
Chemicals
Cyanides Sodium Calcium Strontium
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Baker P F
Singh R
References (24)
24 references, click to expand
  1. The effects of Ca2+ antagonists on Ca2+ accumulation by subcellular fractions of rat myometrium.
    Can J Physiol Pharmacol. 1977 Oct;55(5):1028-32 PMID: 562703
  2. Movements of labelled calcium in squid giant axons.
    J Physiol. 1957 Sep 30;138(2):253-81 PMID: 13526124
  3. Intracellular pH of snail neurones measured with a new pH-sensitive glass mirco-electrode.
    J Physiol. 1974 Apr;238(1):159-80 PMID: 4838803
  4. Mobility and transport of magnesium in squid giant axons.
    J Physiol. 1972 Dec;227(3):855-74 PMID: 4650939
  5. Intracellular pH transients in squid giant axons caused by CO2, NH3, and metabolic inhibitors.
    J Gen Physiol. 1976 Jan;67(1):91-112 PMID: 1460
  6. Studies on the internal pH of large muscle and nerve fibres.
    J Physiol. 1958 Jun 18;142(1):22-62 PMID: 13564418
  7. The kinetics of influx of calcium and strontium into rat intestine in vitro.
    J Physiol. 1970 Nov;210(4):999-1020 PMID: 5501493
  8. Uptake and binding of calcium by axoplasm isolated from giant axons of Loligo and Myxicola.
    J Physiol. 1978 Mar;276:103-25 PMID: 650429
  9. A comparison of the phosphorus metabolism of intact squid nerve with that of the isolated axoplasm and sheath.
    J Physiol. 1965 Sep;180(2):424-38 PMID: 4221748
  10. The effect of cyanide on the efflux of calcium from squid axons.
    J Physiol. 1969 Feb;200(2):497-527 PMID: 5764408
  11. Relationship between calcium release and potassium release in rat parotid gland.
    J Physiol. 1979 Jun;291:457-65 PMID: 480237
  12. Sodium extrusion by internally dialyzed squid axons.
    J Gen Physiol. 1967 Nov;50(10):2303-31 PMID: 6063685
  13. Vanadate inhibits uncoupled Ca efflux but not Na--Ca exchange in squid axons.
    Nature. 1979 Sep 20;281(5728):229-30 PMID: 225674
  14. Depolarization and calcium entry in squid giant axons.
    J Physiol. 1971 Nov;218(3):709-55 PMID: 5133953
  15. Kinetics and energetics of calcium efflux from intact squid giant axons.
    J Physiol. 1976 Jul;259(1):103-44 PMID: 182956
  16. Activation of transmitter release by strontium and calcium ions at the neuromuscular junction.
    J Physiol. 1971 Jul;215(3):709-26 PMID: 4326307
  17. Movement of strontium ions into mast cells and its relationship to the secretory response.
    J Physiol. 1977 Sep;271(1):233-51 PMID: 72148
  18. Transport and metabolism of calcium ions in nerve.
    Prog Biophys Mol Biol. 1972;24:177-223 PMID: 4118937
  19. The regulation of intracellular calcium in giant axons of Loligo and Myxicola.
    Ann N Y Acad Sci. 1978 Apr 28;307:250-68 PMID: 30377
  20. Does metabolic energy participate directly in the Na+-dependent extrusion of Ca2+ -Ca2+ ions from squid giant axons?
    J Physiol. 1973 Aug;233(1):44P-46P PMID: 4759120
  21. The phosphorus metabolism of squid axons and its relationship to the active transport of sodium.
    J Physiol. 1960 Jul;152:545-60 PMID: 13806927
  22. Experiments on the injection of substances into squid giant axons by means of a microsyringe.
    J Physiol. 1956 Mar 28;131(3):592-616 PMID: 13320357
  23. The influence of extracellular calcium binding on the calcium efflux from squid axons.
    J Physiol. 1978 Mar;276:127-50 PMID: 418168
  24. The influence of calcium on sodium efflux in squid axons.
    J Physiol. 1969 Feb;200(2):431-58 PMID: 5764407
Article Info
Journal
The Journal of physiology
Abbr.
J Physiol
ISSN
0022-3751
DOI
10.1113/jphysiol.1982.sp014346
Published
1982-09-00
Pages
373-92
Language
English
Region
England
NLM ID
0266262
PMCID
PMC1225303
Subset
IM
External Links
PubMed source DOI: 10.1113/jphysiol.1982.sp014346 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2