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PMID: 718271 Published · ppublish English Journal Article

The arthritis of mixed connective tissue disease.

Annals of the rheumatic diseases ·Vol. 37 ·No. 5 ·1978-10-00 ·Pages 397-403

Bennett RM, O'Connell DJ

Abstract

Twenty patients with mixed connective tissue disease were followed for 5 years. Arthritis occurred in all 20 patients, being the presenting complaint in 11 patients. The joints most frequently involved were the proximal interphalangeal (PIP), metacarpophalangeal (MCP), wrists, metatarsophalangeal (MTP), and knee; the distribution tended to be symmetrical, mimicking early rheumatoid arthritis. Joint deformities occurred in 6 patients, but apart from 1 patient with arthritis mutilans, significant functional impairment was not encountered. Radiologically small punched out bone erosions, asymmetrically distributed, were the most characteristic finding; other notable changes were aseptic necrosis, tuft erosions, and periarticular calcification. Joint effusions were non-inflammatory, the cellular content was predominantly lymphocytic and the C3 level was normal. Most cases were controlled with non-steroidal anti-inflammatory agents and invariably responded to prednisone less than or equal to 7.5 mg/day.

MeSH Terms
Adolescent Adult Arthritis/diagnosis,diagnostic imaging Female Foot/diagnostic imaging Hand/diagnostic imaging Humans Lupus Erythematosus, Systemic/diagnosis,diagnostic imaging Male Middle Aged Myositis/diagnosis,diagnostic imaging Radiography Scleroderma, Systemic/diagnosis,diagnostic imaging Syndrome
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Bennett R M
O'Connell D J
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Article Info
Journal
Annals of the rheumatic diseases
Abbr.
Ann Rheum Dis
ISSN
0003-4967
DOI
10.1136/ard.37.5.397
Published
1978-10-00
Pages
397-403
Language
English
Region
England
NLM ID
0372355
PMCID
PMC1000265
Subset
IM
External Links
PubMed source DOI: 10.1136/ard.37.5.397 PMC Full Text View journal details
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