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PMID: 7191084 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Associated changes in Ca2+ and Sr2+ activation properties and fiber proteins in cross-reinnervated rabbit soleus.

Pflugers Archiv : European journal of physiology ·Vol. 384 ·No. 3 ·1980-04-00 ·Pages 219-29

Secrist DJ, Kerrick WG

Abstract

Changes in the Ca2+ and Sr2+ activation properties of functionally skinned slow-twitch soleus fibers were measured and compared with those of normal fast-twitch extensor digitorum longus (EDL) following cross-reinnervation of soleus with the nerve to EDL. Most of the fibers showed either complete transformation of activtion properties (66%) or remained unchanged (34%). The change in sensitivity to divalent cations was correlated with changes in the proteins present in fibers pooled on the basis of their activation properties. The banding patterns of the 35,000- and 37,500-dalton proteins (tropomyosin and troponin T) in cross-reinnervated soleus were correspondingly transformed to those of normal EDL. Slow and fast myosin light chains were present in the pooled cross-reinnervated fibers. Fiber distributions based on activation properties were confirmed by histochemical features. For the first time it has been demonstrated that cross-reinnervation produced changes in the activation properties of soleus fibers and associated changes in the regulatory proteins measured.

MeSH Terms
Animals Calcium/pharmacology Molecular Weight Muscle Contraction/drug effects Muscle Proteins/biosynthesis Muscles/innervation Myosins/biosynthesis Rabbits Strontium/pharmacology Troponin/biosynthesis
Chemicals
Muscle Proteins Troponin Myosins Calcium Strontium
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Secrist D J
Kerrick W G
References (34)
34 references, click to expand
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Article Info
Journal
Pflugers Archiv : European journal of physiology
Abbr.
Pflugers Arch
ISSN
0031-6768
DOI
10.1007/BF00584556
Published
1980-04-00
Pages
219-29
Language
English
Region
Germany
NLM ID
0154720
Subset
IM
Grants
NIGMS NIH HHS · GM 00260 · United States
NHLBI NIH HHS · HL 05527 · United States
External Links
PubMed source DOI: 10.1007/BF00584556 View journal details
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