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PMID: 7193541 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Serum thymic factor activity in deficiencies of calories, zinc, vitamin A and pyridoxine.

Clinical and experimental immunology ·Vol. 42 ·No. 2 ·1980-11-00 ·Pages 332-5

Chandra RK, Heresi G, Au B

Abstract

Cell-mediated immunity is invariably impaired in protein-energy malnutrition. The effect of selected nutrient deficiencies on serum thymic factor activity was assessed in deprived rats and pair-fed controls. Deficits of calories, zinc or pyridoxine resulted in significant lowering of serum thymic factor activity whereas vitamin A deficiency did not have any effect. It is suggested that variants nutrients modulate different steps of cell-mediated immunity and that reduced thymic hormone activity may be the underlying mechanism of imparied immunity in some but not all nutritional deficiencies.

MeSH Terms

Animals Deficiency Diseases/blood Energy Intake Male Rats Thymic Factor, Circulating/analysis Thymus Hormones/analysis Vitamin A Deficiency/blood Vitamin B 6 Deficiency/blood Zinc/deficiency

Chemicals

Thymus Hormones Thymic Factor, Circulating Zinc

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Chandra R K

Heresi G

Au B

References (14)

14 references, click to expand

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Serum thymic hormone activity in protein-energy malnutrition.
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Article Info

Journal

Clinical and experimental immunology

Abbr.

Clin Exp Immunol

ISSN

0009-9104

Published

1980-11-00

Pages

332-5

Language

English

Region

England

NLM ID

0057202

PMCID

PMC1537084

Subset

External Links

PubMed source PMC Full Text View journal details

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Serum thymic factor activity in deficiencies of calories, zinc, vitamin A and pyridoxine.

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