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PMID: 72192 Published · ppublish English Clinical Trial Journal Article Randomized Controlled Trial

Oral non-absorbed antibiotics prevent infection in acute non-lymphoblastic leukaemia.

Lancet (London, England) ·Vol. 2 ·No. 8043 ·1977-10-22 ·Pages 837-40

Storring RA, Jameson B, McElwain TJ, Wiltshaw E

Abstract

113 patients being treated for acute non-lymphoblastic leukaemia were investigated to determine the effect of suppression of body microbial flora on prevention of infection. They were randomly allocated to a control group or a group which received non-absorbed antibiotics by mouth and topical applications of cutaneous and mucosal antiseptic preparations. The group receiving oral non-absorbed antibiotics had significantly few infections, fewer deaths from infection, fewer pyrexial episodes, and consequently received less systemic antibiotic therapy than the controls.

MeSH Terms
Acute Disease Administration, Oral Administration, Topical Adolescent Adult Antineoplastic Agents/therapeutic use Bacterial Infections/epidemiology,prevention & control Bacteroides Infections/prevention & control Chlorhexidine/administration & dosage Colistin/administration & dosage Drug Combinations Enterobacteriaceae Infections/prevention & control Framycetin/administration & dosage Humans Leukemia/drug therapy Nystatin/administration & dosage Remission, Spontaneous Sepsis/epidemiology,prevention & control Staphylococcal Infections/prevention & control Staphylococcus aureus Streptococcal Infections/prevention & control
Chemicals
Antineoplastic Agents Drug Combinations Nystatin Framycetin Chlorhexidine Colistin
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Storring R A
Jameson B
McElwain T J
Wiltshaw E
Article Info
Journal
Lancet (London, England)
Abbr.
Lancet
ISSN
0140-6736
DOI
10.1016/s0140-6736(77)90779-6
Published
1977-10-22
Pages
837-40
Language
English
Region
England
NLM ID
2985213R
Subset
IM
External Links
PubMed source DOI: 10.1016/s0140-6736(77)90779-6 View journal details
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