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PMID: 722243 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Inheritance of antibody specificity V. Anti-2-phenyloxazolone in the mouse.

The Journal of experimental medicine ·Vol. 148 ·No. 6 ·1978-12-01 ·Pages 1644-60

Näkelä O, Kaartinen M, Pelkonen JL, Karjalainen K

Abstract

Antibodies to hapten 2-phenyloxazolone (phOx) of all BALB/c and DBA/2 mice have the same idiotype and the same major (public) isoelectric focusing pattern whose main spectrotype is called Ox-1. Neither of these characteristics could be readily demonstrated in anti-phOx antibodies of C57BL, C3H or LP mice; these antibodies were heterogeneous, and lacked public spectrotypes. Also, a fine specificty difference could be demonstrated between anti-phOx antibodies of BALB/c and C5MBL mice; the latter have a higher relative affinity than the former for a structural analogue of phOx (2-o-iodophenyloxazolone). The three BALB/c characteristics were inherited in congenic and recombinant inbred strains as an allotype-linked block, defining a new VH marker, VHphOx. Murine anti-phOx antibodies were found to exhibit three types of conservatism: (a) Every individual mouse of strains BALB/c, DBA/2 or BAB-14 had an almost indistinguishable IEF pattern. (b) These patterns (and the cross-reactive idiotype) remained virtually unchanged during an immunization course of 70 days. (c) An identical idiotype (and in some cases IEF pattern) was present in mouse strains of five different allogroups.

MeSH Terms
Animals Antibody Specificity Female Haptens Immunoglobulin Allotypes/genetics Immunoglobulin Idiotypes/genetics Immunologic Memory Isoelectric Focusing Mice Mice, Inbred Strains/genetics,immunology Oxazoles/immunology Oxazolone/analogs & derivatives,immunology Species Specificity Structure-Activity Relationship
Chemicals
Haptens Immunoglobulin Allotypes Immunoglobulin Idiotypes Oxazoles 2-phenyloxazolone Oxazolone
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Näkelä O
Kaartinen M
Pelkonen J L
Karjalainen K
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33 references, click to expand
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Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.148.6.1644
Published
1978-12-01
Pages
1644-60
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2185107
Subset
IM
External Links
PubMed source DOI: 10.1084/jem.148.6.1644 PMC Full Text View journal details
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