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PMID: 7225291 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Phagocytic cells in glomerular cultures from NZB/W mice.

British journal of experimental pathology ·Vol. 62 ·No. 1 ·1981-02-00 ·Pages 59-64

McGiven AR, Hunt JS, Day WA, Jackson AE

Abstract

Comparative studies of glomerular cultures from NZB/W and normal control mice aged 2, 4, 6, 8, 10 and 12 months revealed a significant increase in the number of phagocytic cells in cultures from NZB/W mice at all ages. These cells on electron microscopy had the appearance of macrophages and on immunofluorescence showed Fc receptors and reacted with rabbit anti-mouse macrophage serum. The cells appear to be of blood monocyte origin and it is likely that they play a role in the pathogenesis in NZB/W mice of the glomerulopathy associated with clearance of immune complexes.

MeSH Terms

Animals Culture Techniques Female Glomerulonephritis/immunology,pathology Kidney Glomerulus/immunology,ultrastructure Leukocyte Count Mice Mice, Inbred NZB Microscopy, Electron, Scanning Phagocytes/immunology,ultrastructure Phagocytosis Receptors, Fc/analysis

Chemicals

Receptors, Fc

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

McGiven A R

Hunt J S

Day W A

Jackson A E

References (14)

14 references, click to expand

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Pathogenesis of the glomerulonephritis of NZB/W mice.
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Glomerular lesions in NZB/NZW mice. Electron microscopic study of development.
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Elution of antinuclear factor from renal lesions of NZB-NZW mice.
Clin Exp Immunol. 1968 Sep;3(7):665-9 PMID: 4883068
The immunology and pathology of NZB mice.
Adv Immunol. 1968;9:215-66 PMID: 4883742
Detection of mouse macrophage antigens by antimacrophage serum.
Aust J Exp Biol Med Sci. 1973 Dec;51(6):793-800 PMID: 4132891
The macrophagen in human rapidly progressive glomerulonephritis.
Lancet. 1976 Apr 17;1(7964):830-2 PMID: 56649
Tissue culture of isolated glomeruli in experimental crescentic glomerulonephritis.
J Exp Med. 1978 Jan 1;147(1):98-109 PMID: 342668
Tissue culture of isolated human glomeruli.
Pathology. 1978 Jan;10(1):59-67 PMID: 643321
Tissue culture of normal rat glomeruli. Isolation and morphological characterization of two homogeneous cell lines.
Invest Cell Pathol. 1979 Jan-Mar;2(1):15-26 PMID: 511605
A microplate adaptation of the solid-phase C1q immune complex assay.
J Immunol Methods. 1980;33(3):267-75 PMID: 6989920
The glomerular mesangium.
Kidney Int. 1980 Feb;17(2):141-54 PMID: 6991772
Mouse glomerular culture.
Br J Exp Pathol. 1981 Feb;62(1):52-8 PMID: 7225290
THE ORIGIN OF MACROPHAGES FROM BONE MARROW IN THE RAT.
Br J Exp Pathol. 1965 Feb;46:62-70 PMID: 14295560

Article Info

Journal

British journal of experimental pathology

Abbr.

Br J Exp Pathol

ISSN

0007-1021

Published

1981-02-00

Pages

59-64

Language

English

Region

England

NLM ID

0372543

PMCID

PMC2041633

Subset

External Links

PubMed source PMC Full Text View journal details

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