Stereochemical aspects of the interaction of myosin and actomyosin with nucleotides.
The five possible analogues of ATP and the three possible analogues of ADP which contain single non-bridging sulphur atoms instead of oxygen in the polyphosphate structure have been used as probes of the interaction of nucleotides with myosin and actomyosin. Evidence is presented for the requirement of an alpha, beta, gamma-tridentate complex of magnesium and ATP as the substrate for myosin. Of the four possible tridentate MgATP diastereomers, the delta exo isomer (nomenclature of Cornelius & Cleland, 1978) appears to be the actual substrate.
16 references, click to expand
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The characterization of myosin-product complexes and of product-release steps during the magnesium ion-dependent adenosine triphosphatase reaction.Biochem J. 1974 Aug;141(2):331-49 PMID: 4281653
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Intermediate states of subfragment 1 and actosubfragment 1 ATPase: reevaluation of the mechanism.Biochemistry. 1978 Aug 22;17(17):3432-42 PMID: 150856
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Formation of a ternary complex: actin, 5'-adenylyl imidodiphosphate, and the subfragments of myosin.Proc Natl Acad Sci U S A. 1978 Jan;75(1):54-8 PMID: 343111
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The ternary complex formed between actin, myosin subfragment 1 and ATP (beta, gamma-NH).FEBS Lett. 1978 May 1;89(1):169-72 PMID: 149024
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Substrate activity of (adenosine triphosphato)tetraamminecobalt(III) with yeast hexokinase and separation of diastereomers using the enzyme.Biochemistry. 1978 Aug 8;17(16):3279-86 PMID: 356875
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