Generation of virus-specific cytolytic activity in human peripheral lymphocytes after vaccination with vaccinia virus and measles virus.
Human peripheral blood lymphocytes (PBL) harvested after vaccination with vaccinia or measles virus showed a specific activity against virus-infected target cells. This activity peaked on day 7 and was specific for the target cells infected with the virus used for the vaccination. The cytotoxic activity was not related to HLA markers. The cells involved in the cytolytic process were lymphocytes bearing Fc receptors. In addition, the cytotoxic activity was abrogated by more than 90% by rabbit Fab'2 anti-human IgG. It is therefore likely that two subpopulations of lymphocytes are involved: an antibody-secreting cell providing specific antiviral antibody and an effector cell bearing Fc receptor (K cells). Finally, these experiments suggest that antibody-dependent cell cytotoxicity may play a major role in the recovery from virus infection in man.
15 references, click to expand
-
Antibody-dependent cell-mediated cytotoxicity in humans. I. Characterization of the effector cell.J Immunol. 1975 Jul;115(1):249-55 PMID: 125298
-
Expression of a receptor for IgM by human T cells in vitro.Eur J Immunol. 1975 Aug;5(8):565-9 PMID: 1086250
-
Antibody-dependent cell-mediated cytotoxicity to target cells infected with type 1 and type 2 herpes simplex virus.J Immunol. 1976 Jan;116(1):194-201 PMID: 173757
-
Factors modifying host resistance to viral infection. 3. Effect of whole body x-irradiation on experimental encephalomyocarditis virus infection in mice.J Exp Med. 1968 May 1;127(5):1035-52 PMID: 4297630
-
Restriction of in vitro T cell-mediated cytotoxicity in lymphocytic choriomeningitis within a syngeneic or semiallogeneic system.Nature. 1974 Apr 19;248(5450):701-2 PMID: 4133807
-
Immunologic injury in measles virus infection. III. Presence and characterization of human cytotoxic lymphocytes.J Immunol. 1977 Jan;118(1):282-90 PMID: 830751
-
Poliomyelitis in hypogammaglobulinemics.J Infect Dis. 1973 Dec;128(6):802-6 PMID: 4765357
-
Formation and dissociation of virus-antibody complexes with special reference to the neutralization process.Prog Med Virol. 1968;10:1-63 PMID: 4886889
-
The rapid induction by phytohemagglutinin of increased alpha-aminoisobutyric acid uptake by lymphocytes.J Clin Invest. 1971 Apr;50(4):818-26 PMID: 4100684
-
Specificity of virus-immune effector T cells for H-2K or H-2D compatible interactions: implications for H-antigen diversity.Transplant Rev. 1976;29:89-124 PMID: 58463
-
Immunological deficiency diseases. Agammaglobulinemia, hypogammaglobulinemia, Hodgkin's disease and sarcoidosis.Prog Allergy. 1962;6:187-319 PMID: 13900248
-
Human T and B lymphocyte rosette tests: effect of enzymatic modification of sheep erythrocytes (E) and the specificity of neuraminidase-treated E.Cell Immunol. 1976 Jun 1;24(1):97-108 PMID: 1084786
-
Specifically cytotoxic lymphocytes produced by preincubation with antibody-complexed target cells.J Immunol. 1972 Feb;108(2):558-61 PMID: 5049099
-
Mechanism of injury of virus-infected cells by antiviral antibody and complement: participation of IgG, F(ab')2, and the alternative complement pathway.J Exp Med. 1976 May 1;143(5):1027-41 PMID: 177712
-
Interactions of antibodies, complement components and various cell types in immunity against viruses and pyogenic bacteria.Transplant Rev. 1974;19(0):3-55 PMID: 4135465
Contact
No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong
Qilu Normal University · Genelibs Bioinformatics Lab
750 Shunhua Rd, Jinan
2F, Bldg F, University Science Park
Tel: 0531-88819269
WeChat Official Account
Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.
Business Email
E-mail: [email protected]
Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2
