Physico-chemical properties of new acyl derivatives of tylosin produced by microbial transformation.

The Journal of antibiotics ·Vol. 33 ·No. 11 ·1980-11-00 ·Pages 1300-8

Okamoto R, Fukumoto T, Nomura H, Kiyoshima K, Nakamura K, Takamatsu A, Naganawa H, Takeuchi T, Umezawa H

Abstract

By microbial transformation of tylosin (I), the following eight new acyl derivatives were obtained: 3-acetyltylosin (II), 3-propionyltylosin (III), 4"-butyryltylosin (IV), 4"-isovaleryltylosin (V), 3-acetyl-4"-butyryltylosin (VI), 3-acetyl-4"-isovaleryltylosin (VII), 3-propionyl-4"-butyryltylosin (VIII) and 3-propionyl-4"-isovaleryltylosin (IX).

MeSH Terms

Biotransformation Chemical Phenomena Chemistry Chemistry, Physical Leucomycins/analysis,metabolism Magnetic Resonance Spectroscopy Mass Spectrometry Spectrophotometry, Infrared Streptomyces/metabolism

Chemicals

Leucomycins

Authors & Affiliations

9 authors, click to expand affiliations / ORCID

Okamoto R

Fukumoto T

Nomura H

Kiyoshima K

Nakamura K

Takamatsu A

Naganawa H

Takeuchi T

Umezawa H

Article Info

Journal

The Journal of antibiotics

Abbr.

J Antibiot (Tokyo)

ISSN

0021-8820

DOI

10.7164/antibiotics.33.1300

Published

1980-11-00

Pages

1300-8

Language

English

Region

Japan

NLM ID

0151115

Subset

External Links

PubMed source DOI: 10.7164/antibiotics.33.1300 View journal details

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Physico-chemical properties of new acyl derivatives of tylosin produced by microbial transformation.

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