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PMID: 7274182 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Recent research on nickel carcinogenesis.

Environmental health perspectives ·Vol. 40 ·1981-08-00 ·Pages 131-41

Sunderman FW

Abstract

Research on nickel carcinogenesis from 1975 to March 1980 is reviewed. Epidemiological studies have strengthened the evidence that workers in nickel refineries have increased risks of cancers of the nasal cavities and lungs. Clinical investigations have resulted in improved diagnosis, classification, and management of cancers of respiratory organs in nickel refinery workers. Carcinogenicity tests have demonstrated the carcinogenicity of nickel subsulfide (alpha-Ni3S2) in rodents following administration by a variety of parenteral routes. Radiotracer studies and x-ray diffractometry have clarified the metabolism of alpha-Ni3S2 in rodents. In vitro exposures of mammalian cells to certain nickel compounds have been shown to inhibit cellular uptake of thymidine-3H, and to induce chromosomal aberrations, somatic mutations, and morphological transformation. Mutagenicity tests of nickel compounds in bacterial systems have consistently been negative. Ni(II) has beeb reported to impair the fidelity of viral and bacterial DNA polymerases for in vitro replication of synthetic nucleotide templates.

MeSH Terms
Administration, Oral Animals DNA/biosynthesis Humans Injections Injections, Intramuscular Injections, Intraperitoneal Lung Neoplasms/chemically induced Microscopy, Electron Mutagenicity Tests Neoplasms/chemically induced Nickel/administration & dosage,adverse effects,pharmacology Radioisotopes Research Respiratory Tract Neoplasms/chemically induced X-Ray Diffraction
Chemicals
Radioisotopes Nickel DNA
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Sunderman F W
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48 references, click to expand
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Article Info
Journal
Environmental health perspectives
Abbr.
Environ Health Perspect
ISSN
0091-6765
DOI
10.1289/ehp.8140131
Published
1981-08-00
Pages
131-41
Language
English
Region
United States
NLM ID
0330411
PMCID
PMC1568829
Subset
IM
Grants
NIEHS NIH HHS · ES-01337 · United States
External Links
PubMed source DOI: 10.1289/ehp.8140131 PMC Full Text View journal details
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