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PMID: 7274657 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Genetics of aldehyde dehydrogenase isozymes in the mouse: evidence for multiple loci and localization of Ahd-2 on chromosome 19.

Genetics ·Vol. 97 ·No. 2 ·1981-02-00 ·Pages 327-36

Timms GP, Holmes RS

Abstract

Electrophoretic and activity variation of the cytoplasmic isozyme of aldehyde dehydrogenase (designated AHD-B4) was observed among inbred strains and Harwell linkage-testing stocks of Mus musculus. The phenotypes are inherited in a normal Mendelian fashion, with two alleles showing co-dominant expression at a single locus (Ahd-2). The locus was shown to segregate independently of Ahd-1 (encoding the mitochondrial AHD-A2 isozymes on chromosome 4; HOLMES 1978). Linkage data of Ahd-2 with ep (pale ears), ru (ruby eyes) and bm (brachymorphic) suggest that it is localized near the centromeric end of chromosome 19. Electrophoretic evidence for a third AHD isozyme (designated AHD-Cy), which is predominantly localized in the liver microsomal fraction, is also presented.

MeSH Terms
Aldehyde Dehydrogenase Aldehyde Oxidoreductases/genetics Animals Chromosome Mapping Genes Isoenzymes/genetics Liver/enzymology Mice Mice, Inbred Strains/genetics Phenotype
Chemicals
Isoenzymes Aldehyde Oxidoreductases Aldehyde Dehydrogenase
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Timms G P
Holmes R S
References (9)
9 references, click to expand
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Article Info
Journal
Genetics
Abbr.
Genetics
ISSN
0016-6731
DOI
10.1093/genetics/97.2.327
Published
1981-02-00
Pages
327-36
Language
English
Region
United States
NLM ID
0374636
PMCID
PMC1214396
Subset
IM
External Links
PubMed source DOI: 10.1093/genetics/97.2.327 PMC Full Text View journal details
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