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PMID: 7276830 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Chromosome assignment of the tumor-specific antigen of a 3-methylcholanthrene-induced mouse sarcoma.

The Journal of experimental medicine ·Vol. 154 ·No. 3 ·1981-09-01 ·Pages 964-77

Pravtcheva DD, DeLeo AB, Ruddle FH, Old LJ

Abstract

Chemically induced sarcomas of inbred mice express antigens that are distinct and specific for each individual tumor. Chromosome assignment of tumor-specific antigens would help to elucidate the genetic basis of their diversity. Expression of the serologically defined Meth A sarcoma antigen is not suppressed in hybrid cells containing a complete foreign (Chinese hamster) genome. Chromosome and serologic analysis of microcell hybrids between Meth A sarcoma cells and Chinese hamster cells shows a clear correlation of Meth A antigen expression with the presence of the distal region of chromosome 12 (bands F1 and F2). Chromosome 16 may also be implicated. The significance of the close linkage of genes determining Meth A antigen expression with the immunoglobulin heavy chain gene cluster (on chromosome 12) and the lambda light chain genes (on chromosome 16) is discussed.

MeSH Terms
Animals Antigens, Neoplasm/genetics Cell Line Chromosome Mapping Cricetinae Hybrid Cells/immunology Karyotyping Methylcholanthrene Mice Sarcoma, Experimental/immunology
Chemicals
Antigens, Neoplasm Methylcholanthrene
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Pravtcheva D D
DeLeo A B
Ruddle F H
Old L J
References (40)
40 references, click to expand
  1. The molecular basis of antibody formation: a paradox.
    Proc Natl Acad Sci U S A. 1965 Sep;54(3):864-9 PMID: 4160200
  2. Evidence for the antigenicity of papillomas induced by 3-methylcholanthrene.
    J Natl Cancer Inst. 1968 Apr;40(4):823-46 PMID: 4869135
  3. Selection for 12-day litter weight in mice.
    Genetics. 1970 Mar-Apr;64(3):511-32 PMID: 5464757
  4. A simple technique for demonstrating centromeric heterochromatin.
    Exp Cell Res. 1972 Nov;75(1):304-6 PMID: 4117921
  5. 8-Azaguanine resistance in mammalian cells. I. Hypoxanthine-guanine phosphoribosyltransferase.
    Genetics. 1972 Oct;72(2):239-52 PMID: 4345996
  6. A system of nomenclature for band patterns of mouse chromosomes.
    Chromosoma. 1973;41(2):145-58 PMID: 4120886
  7. Studies on the basis for diversity and time of appearance of antigens in chemically induced tumors.
    Natl Cancer Inst Monogr. 1972 Dec;35:117-24 PMID: 4121493
  8. A review of enzyme polymorphism, linkage and electrophoretic conditions for mouse and somatic cell hybrids in starch gels.
    J Histochem Cytochem. 1973 Dec;21(12):1066-81 PMID: 4587225
  9. New genetic model for allelism at histocompatibility and other complex loci: polymorphism for control of gene expression.
    Transplant Proc. 1973 Dec;5(4):1471-5 PMID: 4204524
  10. Preparation of microcells by enucleation of micronucleate cells.
    Exp Cell Res. 1974 Aug;87(2):378-82 PMID: 4370277
  11. Tumour-associated transplantation antigens of chemically induced sarcomata cross reacting with allogeneic histocompatibility antigens.
    Nature. 1975 Apr 24;254(5502):713-4 PMID: 1091865
  12. A preparative method for obtaining enucleated mammalian cells.
    Biochem Biophys Res Commun. 1975 Apr 7;63(3):669-74 PMID: 1169063
  13. Mammalian chromosome identification in interspecific hybride cells using "Hoechst 33258".
    Humangenetik. 1975;27(1):9-14 PMID: 49289
  14. Are methylcholanthrene-induced sarcoma-associated, rejection-inducing (TSTA) antigens, modified forms of H-2 or linked determinants?
    Int J Cancer. 1975 Jun 15;15(6):879-87 PMID: 50291
  15. Shared idiotypic determinants on B and T lymphocytes reactive against the same antigenic determinants. I. Demonstration of similar or identical idiotypes on IgG molecules and T-cell receptors with specificity for the same alloantigens.
    J Exp Med. 1975 Jul 1;142(1):197-211 PMID: 50400
  16. T-cell idiotypes are linked to immunoglobulin heavy chain genes.
    Nature. 1976 Dec 16;264(5587):639-42 PMID: 137363
  17. Microcell-mediated transfer of murine chromosomes into mouse, Chinese hamster, and human somatic cells.
    Proc Natl Acad Sci U S A. 1977 Jan;74(1):319-23 PMID: 264685
  18. Gene linkage analysis in the mouse by somatic cell hybridization: assignment of adenine phosphoribosyltransferase to chromosome 8 and alpha-galactosidase to the X chromosome.
    Somatic Cell Genet. 1975 Oct;1(4):371-82 PMID: 1235912
  19. Expression of transformation in cell hybrids. I. Isolation and application of density-inhibited Balb/3T3 cells deficient in hypoxanthine phosphoribosyltransferase and resistant to ouabain.
    Somatic Cell Genet. 1976 May;2(3):215-23 PMID: 1028169
  20. Biological and biochemical properties of Nonidet P40-solubilized and partially purified tumor-specific antigens of the transplantation type from plasma membranes of a methylcholanthrene-induced sarcoma.
    Cancer Res. 1977 Sep;37(9):3406-13 PMID: 69494
  21. Cell surface antigens of chemically induced sarcomas of the mouse. I. Murine leukemia virus-related antigens and alloantigens on cultured fibroblasts and sarcoma cells: description of a unique antigen on BALB/c Meth A sarcoma.
    J Exp Med. 1977 Sep 1;146(3):720-34 PMID: 197192
  22. Glyoxalase I polymorphism in the mouse: a new genetic marker linked to H-2.
    Science. 1977 Oct 21;198(4314):311-3 PMID: 910130
  23. Assignment of the gene for adenosine kinase to chromosome 14 in Mus musculus by somatic cell hybridization.
    Cytogenet Cell Genet. 1978;21(1-2):77-85 PMID: 206412
  24. Isolated hapten-binding receptors of sensitized lymphocytes. III. Evidence for idiotypic restriction of T-cell receptors.
    J Exp Med. 1978 May 1;147(5):1341-7 PMID: 418137
  25. Assignment of the genes for triose phosphate isomerase to chromosome 6 and tripeptidase-1 to chromosome 10 in Mus musculus by somatic cell hybridization.
    Somatic Cell Genet. 1978 Mar;4(2):233-40 PMID: 566475
  26. A complete immunoglobulin gene is created by somatic recombination.
    Cell. 1978 Sep;15(1):1-14 PMID: 100225
  27. Assignment of genes for immunoglobulin kappa and heavy chains to chromosomes 6 and 12 in mouse.
    Proc Natl Acad Sci U S A. 1978 Sep;75(9):4494-8 PMID: 100785
  28. Shared idiotypic determinants on antibodies and T-cell-derived suppressor factor specific for the random terpolymer L-glutamic acid60-L-alanine30-L-tyrosine10.
    J Exp Med. 1979 Mar 1;149(3):613-22 PMID: 107261
  29. Biochemical characterization of alien H-2 antigens expressed on a methylcholanthrene-induced tumor.
    Proc Natl Acad Sci U S A. 1979 Mar;76(3):1415-9 PMID: 286324
  30. Sequences of five potential recombination sites encoded close to an immunoglobulin kappa constant region gene.
    Proc Natl Acad Sci U S A. 1979 Jul;76(7):3450-4 PMID: 115000
  31. Deletions are associated with somatic rearrangement of immunoglobulin heavy chain genes.
    Cell. 1980 Jan;19(1):37-51 PMID: 6766810
  32. Tumor rejection activity of antigens isolated from the membranes of a methylcholanthrene-induced sarcoma, C-1, bearing alien H-2 antigens.
    Transplant Proc. 1980 Mar;12(1):46-9 PMID: 6154358
  33. Chromosomal location of the structural gene cluster encoding murine immunoglobulin heavy chains.
    J Exp Med. 1980 Jun 1;151(6):1545-50 PMID: 6770027
  34. Comparative gene mapping: order of loci on the X chromosome is different in mice and humans.
    Proc Natl Acad Sci U S A. 1980 Jun;77(6):3595-9 PMID: 6251472
  35. Chromosomal location of structural genes encoding murine immunoglobulin lambda light chains. Genetics of murine lambda light chains.
    J Exp Med. 1981 Apr 1;153(4):793-800 PMID: 6265582
  36. Immunity to methylcholanthrene-induced sarcomas.
    J Natl Cancer Inst. 1957 Jun;18(6):769-78 PMID: 13502695
  37. Demonstration of resistance against methylcholanthrene-induced sarcomas in the primary autochthonous host.
    Cancer Res. 1960 Dec;20:1561-72 PMID: 13756652
  38. SELECTION OF HYBRIDS FROM MATINGS OF FIBROBLASTS IN VITRO AND THEIR PRESUMED RECOMBINANTS.
    Science. 1964 Aug 14;145(3633):709-10 PMID: 14168277
  39. ANTIGENIC SPECIFICITY OF BENZO(A)PYRENE-INDUCED SARCOMAS.
    J Natl Cancer Inst. 1964 Jun;32:1229-43 PMID: 14191397
  40. Linkage analyses of murine immunoglobulin heavy chain and serum prealbumin genes establish their location on chromosome 12 proximal to the T (5;12) 31H breakpoint in band 12F1.
    Proc Natl Acad Sci U S A. 1980 Jan;77(1):550-3 PMID: 6767238
Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.154.3.964
Published
1981-09-01
Pages
964-77
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2186453
Subset
IM
Grants
PHS HHS · 5R01 09966-19 · United States
NCI NIH HHS · CA-28461-01 · United States
External Links
PubMed source DOI: 10.1084/jem.154.3.964 PMC Full Text View journal details
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