Effects of prostaglandins E1 and E2 on the in vitro production of immunoglobulin by human peripheral blood lymphocytes.

The effects of PGE2 and PGE1 on the response of human peripheral blood lymphocytes to Pokeweed mitogen were studied. Addition of PGE2 inhibited IgM production. This effect was augmented by treating the lymphocytes with 2.0 mug/ml of Indomethacin. Addition of PGE1 alone had little effect but augmentation of IgM production was seen in cultures where the lymphocytes had been treated with Indomethacin and PGE1 then added. The results suggest that PGE1/E2 have a small but measurable effect on in vitro IgM production.