Electrogenic Na pump evidenced by injecting various Na salts into the isolated A-V node cells of rabbit heart.

Pflugers Archiv : European journal of physiology ·Vol. 392 ·No. 1 ·1981-11-00 ·Pages 89-91

Kurachi Y, Noma A, Irisawa H

Abstract

Electrogenicity of the Na pump was confirmed by injecting Na salts into a small cluster of A-V node cells. Injection of Na glutamate or Na acetate induced marked hyperpolarization, accompanying with cessation of spontaneous activity. The hyperpolarization exceeded EK in 27 mM K Tyrode solution and was inhibited by 10(-5) M strophanthidin. Injection of NaCl or NaI depolarized the membrane. These data showed that inward-going current carried by the injected anion antagonized the outward-going pump current and thus determined the net effect of the injection.

MeSH Terms

Action Potentials/drug effects Animals Atrioventricular Node/metabolism Biological Transport, Active Electric Stimulation Heart/physiology Heart Conduction System/metabolism In Vitro Techniques Myocardium/metabolism Neuromuscular Junction/metabolism Potassium/physiology Rabbits Sodium/metabolism

Chemicals

Sodium Potassium

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Kurachi Y

Noma A

Irisawa H

References (8)

8 references, click to expand

Spontaneously active cells isolated from the sino-atrial and atrio-ventricular nodes of the rabbit heart.
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AN ELECTROGENIC SODIUM PUMP IN SNAIL NERVE CELLS.
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EFFECTS PRODUCED ON INHIBITORY POSTSYNAPTIC POTENTIALS BY THE COUPLED INJECTIONS OF CATIONS AND ANIONS INTO MOTONEURONS.
Proc R Soc Lond B Biol Sci. 1964 May 19;160:197-210 PMID: 14169656
Membrane permeability during low potassium depolarization in sheep cardiac Purkinje fibers.
Am J Physiol. 1979 Sep;237(3):C156-65 PMID: 474744
Steady state contribution of the Na, K-pump to the membrane potential in identified neurons of a terrestrial snail, Helix pomatia.
Acta Physiol Scand. 1972 Dec;86(4):498-514 PMID: 4344877
Electrogenic sodium pump in nerve and muscle cells.
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Article Info

Journal

Pflugers Archiv : European journal of physiology

Abbr.

Pflugers Arch

ISSN

0031-6768

DOI

10.1007/BF00584587

Published

1981-11-00

Pages

89-91

Language

English

Region

Germany

NLM ID

0154720

Subset

External Links

PubMed source DOI: 10.1007/BF00584587 View journal details

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Electrogenic Na pump evidenced by injecting various Na salts into the isolated A-V node cells of rabbit heart.

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