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PMID: 7327697 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Effect of staphylococcal alpha-toxin on neutrophil migration and adhesiveness.

Inflammation ·Vol. 5 ·No. 4 ·1981-12-00 ·Pages 313-22

Schmeling DJ, Gemmell CG, Craddock PR, Quie PG, Peterson PK

Abstract

The effect of staphylococcal alpha-toxin on the chemotactic response of human polymorphonuclear leukocytes was studied by measuring the migration of alpha-toxin-treated cells either through membrane filters toward C5a or under agarose toward N-formyl-l-methionyl-l-phenylalanine. At doses of greater than or equal to 5 hemolytic units, alpha-toxin depressed chemotactic responsiveness in both best systems. Further studies revealed that alpha-toxin was also a potent granulocyte aggregant at doses similar to those necessary for depressed chemotactic capacity. It is proposed that the inhibitory effect of this membrane-active toxin on chemotactic function may be related to increased granulocyte adhesiveness and that the pathogenic properties of alpha-toxin may in part by explained by these effects.

MeSH Terms
Bacterial Toxins/pharmacology Cell Adhesion Cell Aggregation Chemotaxis, Leukocyte Dose-Response Relationship, Drug Hemolysin Proteins Neutrophils/physiology
Chemicals
Bacterial Toxins Hemolysin Proteins staphylococcal alpha-toxin
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Schmeling D J
Gemmell C G
Craddock P R
Quie P G
Peterson P K
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23 references, click to expand
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Article Info
Journal
Inflammation
Abbr.
Inflammation
ISSN
0360-3997
DOI
10.1007/BF00911095
Published
1981-12-00
Pages
313-22
Language
English
Region
United States
NLM ID
7600105
Subset
IM
Grants
NIAID NIH HHS · AI06931-1 · United States
NIAID NIH HHS · AI08821-07 · United States
NCI NIH HHS · CA15627 · United States
External Links
PubMed source DOI: 10.1007/BF00911095 View journal details
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