Hydrocortisone-induced inhibitor of prostaglandin biosynthesis in rat leucocytes.

British journal of pharmacology ·Vol. 68 ·No. 1 ·1980-01-00 ·Pages 14-6

Carnuccio R, Di Rosa M, Persico P

Abstract

Rat peritoneal luecocytes incubated with hydrocortisone (10 micrograms/ml) release a factor which inhibits prostaglandin generation. The steroid-induced inhibitor, which mediates the anti-phospholipase effect of antiinflammatory steroids, may be a protein or a polypeptide since its formation is blocked by cycloheximide, a known inhibitor of protein synthesis.

MeSH Terms

Animals Arachidonic Acids/metabolism Cycloheximide/pharmacology Drug Interactions Hydrocortisone/pharmacology In Vitro Techniques Leukocytes/drug effects,metabolism Male Prostaglandin Antagonists/blood Prostaglandins/biosynthesis Rats

Chemicals

Arachidonic Acids Prostaglandin Antagonists Prostaglandins Cycloheximide Hydrocortisone

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Carnuccio R

Di Rosa M

Persico P

References (6)

6 references, click to expand

Mechanism of action of glucocorticoids.
Metabolism. 1974 Feb;23(2):159-202 PMID: 4359315
A chemotactic role for prostaglandins released from polymorphonuclear leucocytes during phagocytosis.
Br J Pharmacol. 1975 Apr;53(4):539-46 PMID: 1148497
The importance of phospholipase-A2 in prostaglandin biosynthesis.
Biochem Pharmacol. 1976 Feb 1;25(3):285-91 PMID: 817726
Inhibition of prostaglandin biosynthesis by corticosteroids requires RNA and protein synthesis.
Nature. 1978 Jun 15;273(5663):552-4 PMID: 78452
Anti-inflammatory steroids induce biosynthesis of a phospholipase A2 inhibitor which prevents prostaglandin generation.
Nature. 1979 Mar 29;278(5703):456-9 PMID: 450050
Mechanism of inhibition of prostaglandin biosynthesis by hydrocortisone in rat leucocytes.
Br J Pharmacol. 1979 Jun;66(2):161-3 PMID: 465865

Article Info

Journal

British journal of pharmacology

Abbr.

Br J Pharmacol

ISSN

0007-1188

DOI

10.1111/j.1476-5381.1980.tb10691.x

Published

1980-01-00

Pages

14-6

Language

English

Region

England

NLM ID

7502536

PMCID

PMC2044121

Subset

External Links

PubMed source DOI: 10.1111/j.1476-5381.1980.tb10691.x PMC Full Text View journal details

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Hydrocortisone-induced inhibitor of prostaglandin biosynthesis in rat leucocytes.

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