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PMID: 7358434 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Binding of cholesterol by sulfhydryl-activated cytolysins.

Infection and immunity ·Vol. 27 ·No. 1 ·1980-01-00 ·Pages 97-101

Johnson MK, Geoffroy C, Alouf JE

Abstract

The binding of cholesterol by pneumolysin, alveolysin, and streptolysin O has been demonstrated. The properties of the cytolysin-cholesterol interaction parallel those of cytolysin-erythrocyte interaction in that the reaction is rapid, temperature independent, decreased at elevated pH, and shows the same specificity with respect to other related sterols. However, oxidized or p-hydroxymercuribenzoate-treated thoxin showed no decrease in cholesterol-binding activity, whereas the ability of cytolysin to bind to erythrocytes was modified by such treatment.

MeSH Terms

Cholesterol/metabolism Cytotoxins/metabolism Models, Biological Sulfhydryl Compounds/pharmacology

Chemicals

Cytotoxins Sulfhydryl Compounds Cholesterol

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Johnson M K

Geoffroy C

Alouf J E

References (17)

17 references, click to expand

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Article Info

Journal

Infection and immunity

Abbr.

Infect Immun

ISSN

0019-9567

DOI

10.1128/iai.27.1.97-101.1980

Published

1980-01-00

Pages

97-101

Language

English

Region

United States

NLM ID

0246127

PMCID

PMC550729

Subset

External Links

PubMed source DOI: 10.1128/iai.27.1.97-101.1980 PMC Full Text View journal details

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Binding of cholesterol by sulfhydryl-activated cytolysins.

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