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PMID: 7374793 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Identification of harman in the rat arcuate nucleus.

Naunyn-Schmiedeberg's archives of pharmacology ·Vol. 310 ·No. 3 ·1980-01-00 ·Pages 227-30

Shoemaker DW, Cummins JT, Bidder TG, Boettger HG, Evans M

Abstract

This communication describes the presence of 1-methyl-beta-carboline (harman) in the hypophysiotropic area of the hypothalamus which incorporates the arcuate nucleus. Diethyl ether extracts of borate-buffered arcuate homogenates were subjected to silica column chromatography and thin-layer chromatography (TLC). Identification of the beta-carboline was accomplished by use of fluorescent spectrometry, gas chromatography (GC), mass spectrometry (MS) and combined gas chromatography-mass spectrometry (GC-MS).

MeSH Terms
Alkaloids/metabolism Animals Carbolines/metabolism Caudate Nucleus/metabolism Chromatography, Gas Harmine/analogs & derivatives,metabolism Male Medulla Oblongata/metabolism Mesencephalon/metabolism Rats Spectrometry, Fluorescence
Chemicals
Alkaloids Carbolines Harmine harman
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Shoemaker D W
Cummins J T
Bidder T G
Boettger H G
Evans M
References (30)
30 references, click to expand
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Article Info
Journal
Naunyn-Schmiedeberg's archives of pharmacology
Abbr.
Naunyn Schmiedebergs Arch Pharmacol
ISSN
0028-1298
DOI
10.1007/BF00499914
Published
1980-01-00
Pages
227-30
Language
English
Region
Germany
NLM ID
0326264
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00499914 View journal details
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