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PMID: 7393222 Published · ppublish English Journal Article

Conformational transitions in closed circular DNA molecules. II. Biological implications.

Molecular biology reports ·Vol. 6 ·No. 1 ·1980-03-31 ·Pages 11-5

Luchnik AN

Abstract

A model of regulation of gene action based on the theory of conformational transitions in closed circular DNA molecules is proposed and discussed in connection with the mechanisms of cellular differentiation. The model predicts two main types of regulation of gene action (1) the change in the topological linking number of the DNA loops leading to the change in the amount of the DNA segments present in the transcriptionally active A-form and (2) the change of some nucleotide sequences in closed superhelical DNA loops resulting in conformational transitions of some of the other sequences in the same loop. The first type of regulation may explain the mechanism of terminal differentiation of the stem cells and the changes accompanying the malignant transformation. The second one may explain the variegated position effect of the gene and determination of the stem cells during ontogenesis.

MeSH Terms
Chromatin/metabolism,ultrastructure DNA, Circular DNA, Superhelical Genes Mathematics Nucleic Acid Conformation Protein Biosynthesis Transcription, Genetic
Chemicals
Chromatin DNA, Circular DNA, Superhelical
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Luchnik A N
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60 references, click to expand
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Article Info
Journal
Molecular biology reports
Abbr.
Mol Biol Rep
ISSN
0301-4851
DOI
10.1007/BF00775747
Published
1980-03-31
Pages
11-5
Language
English
Region
Netherlands
NLM ID
0403234
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00775747 View journal details
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