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PMID: 7395866 Published · ppublish English Journal Article

Heritable fragile sites on human chromosomes. V. A new class of fragile site requiring BrdU for expression.

American journal of human genetics ·Vol. 32 ·No. 4 ·1980-07-00 ·Pages 542-8

Sutherland GR, Baker E, Seshadri RS

Abstract

A new fragile site at 10q25 is described, representing a new class of fragile site that requires bromodeoxyuridine (BrdU) in the culture medium for expression. This new fragile site is present in approximately one in 30 of the Australian population; it has only been observed in heterozygotes.

MeSH Terms
Bromodeoxyuridine/pharmacology Chromosome Aberrations Chromosome Mapping Chromosomes, Human, 6-12 and X/ultrastructure Culture Media Heterozygote Humans Pedigree Polymorphism, Genetic
Chemicals
Culture Media Bromodeoxyuridine
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Sutherland G R
Baker E
Seshadri R S
References (12)
12 references, click to expand
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    Chromosoma. 1974 Jan 29;44(4):343-59 PMID: 4134865
  4. Giemsa technique for the detection of sister chromatid exchanges.
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  6. Fragile sites on human chromosomes: demonstration of their dependence on the type of tissue culture medium.
    Science. 1977 Jul 15;197(4300):265-6 PMID: 877551
  7. Direct evidence for the role of incorporated BUdR in the induction of sister chromatid exchanges.
    Exp Cell Res. 1978 Nov;117(1):23-30 PMID: 720406
  8. Heritable fragile sites on human chromosomes I. Factors affecting expression in lymphocyte culture.
    Am J Hum Genet. 1979 Mar;31(2):125-35 PMID: 36752
  9. Heritable fragile sites on human chromosomes II. Distribution, phenotypic effects, and cytogenetics.
    Am J Hum Genet. 1979 Mar;31(2):136-48 PMID: 453198
  10. The importance of being a fragile site.
    Am J Hum Genet. 1979 Mar;31(2):223-5 PMID: 453205
  11. Heritable fragile sites on human chromosomes. IV. Silver staining.
    Hum Genet. 1979;53(1):29-30 PMID: 535899
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    Proc Natl Acad Sci U S A. 1961 Mar 15;47:396-403 PMID: 13716386
Article Info
Journal
American journal of human genetics
Abbr.
Am J Hum Genet
ISSN
0002-9297
Published
1980-07-00
Pages
542-8
Language
English
Region
United States
NLM ID
0370475
PMCID
PMC1686118
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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