Normal human sleep: regional cerebral hemodynamics.

Measurements of regional cerebral blood flow (rCBF) by the xenon 133 inhalation method along with polygraph recordings were made serially during relaxed wakefulness and different stages of nocturnal sleep in 18 right-handed normal volunteers. During stage I-II sleep the fast flow (Fg) values declined significantly, more in the brainstem-cerebellar (BSC) regions than in hemispheric regions. During stage III-IV sleep, Fg further declined diffusely in both hemispheric (-28%) and BSC (-29%) regions. During awakening from stage IV sleep to alpha-frequency wakefulness, BSC flow values increased more than hemispheric flow values. During REM sleep, regional Fg values increased diffusely in both hemispheric (+41%) and BSC (+47%) regions compared with wakefulness. There was a significant inverse correlation between the increase in end-tidal partial pressure for carbon dioxide and the reduction in bihemispheric Fg during sleep. Cerebral vasomotor responsiveness to carbon dioxide is decreased during both REM and non-REM sleep.