Stimulation of granulocyte adhesiveness by the chemotactic peptide N-formyl-L-methionyl-L-phenylalanine.

The in vitro effects of the peptide N-formyl-L-methionyl-L-phenylalanine on granulocytes adhesiveness and chemotaxis were investigated. N-formyl-L-methionyl-L-phenylalanine, when used at concentration chemotactically effective, increased significantly granulocyte adhesiveness. When granulocyte adhesiveness was inhibited by colchicine, the inhibition could not be reversed by subsequent treatment with N-formyl-L-methionyl-L-phenylalanine. These results suggest that microtubular system is involved in the stimulation of granulocyte adhesiveness by N-formyl-L-methionyl-L-phenylalanine.