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PMID: 7403881 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Cerebral arteriolar damage by arachidonic acid and prostaglandin G2.

Science (New York, N.Y.) ·Vol. 209 ·No. 4462 ·1980-09-12 ·Pages 1242-5

Kontos HA, Wei EP, Povlishock JT, Dietrich WD, Magiera CJ, Ellis EF

Abstract

Application of arachidonic acid or prostaglandin G(2) to the brain surface of anesthetized cats induced cerebral arteriolar damage. Scavengers of free oxygen radicals inhibited this damage. Prostaglandin H(2), prostaglandin E(2), and 11,14,17-eicosatrienoic acid did not produce arteriolar damage. It appears that increased prostaglandin synthesis produces cerebral vascular damage by generating free oxygen radicals.

MeSH Terms

Animals Arachidonic Acids/pharmacology Arterioles/drug effects,pathology Cats Cerebral Arteries/drug effects,pathology Endothelium/drug effects,pathology Hypertension/pathology Prostaglandin Endoperoxides/pharmacology Prostaglandins E/pharmacology Prostaglandins G/pharmacology Prostaglandins H/pharmacology Vasodilation/drug effects

Chemicals

Arachidonic Acids Prostaglandin Endoperoxides Prostaglandins E Prostaglandins G Prostaglandins H

Authors & Affiliations

6 authors, click to expand affiliations / ORCID

Kontos H A

Wei E P

Povlishock J T

Dietrich W D

Magiera C J

Ellis E F

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.7403881

Published

1980-09-12

Pages

1242-5

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.7403881 View journal details

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Cerebral arteriolar damage by arachidonic acid and prostaglandin G2.

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