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PMID: 7408906 Published · ppublish English Journal Article

Idiopathic mesangial IgA-glomerulonephritis in childhood Description of 19 pediatric cases and review of the literature.

European journal of pediatrics ·Vol. 134 ·No. 1 ·1980-06-00 ·Pages 13-22

Michalk D, Waldherr R, Seelig HP, Weber HP, Schärer K

Abstract

Nineteen out of 83 children with asymptomatic haematuria were classified as having IgA glomerulonephritis, characterized by diffuse mesangial deposition of IgA in the absence of systematic disease. Different histological patterns were observed: i.e., minor glomerular lesions (5 cases), focal and segmental proliferative glomerulonephritis (8 cases) and diffuse proliferative glomerulonephritis (6 cases). Recurrent gross haematuria is the clinical hallmark of the disease. Proteinuria was present in 14 children and exceeded 1 g/m2/day in 3 patients. Clinico-pathological correlations showed a close relation between the degree of proteinuria and the histological lesions. Serum IgA levels were elevated in 3 children. Glomerular filtration rate remained above 80 ml/min/1.73 m2 in a 1 to 9 year follow-up.

MeSH Terms
Adolescent Child Child, Preschool Female Glomerular Filtration Rate Glomerulonephritis/complications,diagnosis Hematuria/etiology Humans Immunoglobulin A/analysis Kidney Glomerulus/analysis Male Proteinuria/etiology
Chemicals
Immunoglobulin A
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Michalk D
Waldherr R
Seelig H P
Weber H P
Schärer K
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47 references, click to expand
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Article Info
Journal
European journal of pediatrics
Abbr.
Eur J Pediatr
ISSN
0340-6199
DOI
10.1007/BF00442397
Published
1980-06-00
Pages
13-22
Language
English
Region
Germany
NLM ID
7603873
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00442397 View journal details
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