Faecal bile acid concentration of patients with carcinoma or increased risk of carcinoma in the large bowel.

Gut ·Vol. 21 ·No. 7 ·1980-07-00 ·Pages 587-90

Mudd DG, McKelvey ST, Norwood W, Elmore DT, Roy AD

Abstract

Faecal 3-hydroxy bile acids were assayed enzymatically in patients with carcinoma, or at increased risk of developing carcinoma of the large bowel. No rise in bile acid concentration was demonstrated in patients with ulcerative colitis, previously resected adenoma, or resected carcinoma. Patients with carcinoma, before treatment, had faecal bile acid concentrations similar to control values, and surgery did not affect the mean level. These findings cast doubt on the importance of the 3-hydroxy bile acid concentration in the faeces in the pathogenesis of large bowel cancer.

MeSH Terms

Adult Aged Bile Acids and Salts/analysis Carcinoma/metabolism,surgery Colitis, Ulcerative/metabolism Colonic Neoplasms/metabolism,surgery Feces/analysis Female Humans Intestinal Polyps/metabolism,surgery Male Middle Aged Postoperative Period Rectal Neoplasms/metabolism,surgery Risk

Chemicals

Bile Acids and Salts

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Mudd D G

McKelvey S T

Norwood W

Elmore D T

Roy A D

References (15)

15 references, click to expand

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Article Info

Journal

Gut

Abbr.

Gut

ISSN

0017-5749

DOI

10.1136/gut.21.7.587

Published

1980-07-00

Pages

587-90

Language

English

Region

England

NLM ID

2985108R

PMCID

PMC1419892

Subset

External Links

PubMed source DOI: 10.1136/gut.21.7.587 PMC Full Text View journal details

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Faecal bile acid concentration of patients with carcinoma or increased risk of carcinoma in the large bowel.

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