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PMID: 7429545 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

The biological half-lives of four rat immunoglobulin isotypes.

Immunology ·Vol. 40 ·No. 4 ·1980-08-00 ·Pages 683-6

Peppard JV, Orlans E

Abstract

Purified preparations of monoclonal rat IgG2a, IgG1, IgM and monomeric IgA, and of polyclonal IgG, were lightly radiolabelled with 125I and injected intravenously into rats. Blood samples were taken so that the half-life of each immunoglobulin isotype could be calculated. Half-life was defined as the time taken for the specific radioactivity present in the blood 24 h after injection to fall by half. The half-life values thus obtained were 106 h for IgG2a, 53 h for IgG1, 63 h for polyclonal IgG, 25 h for IgM and 27 h for monomeric IgA.

MeSH Terms
Animals Half-Life Immunoglobulin A/metabolism Immunoglobulin G/classification,metabolism Immunoglobulin M/metabolism Immunoglobulins/classification Iodine Radioisotopes Male Rats
Chemicals
Immunoglobulin A Immunoglobulin G Immunoglobulin M Immunoglobulins Iodine Radioisotopes
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Peppard J V
Orlans E
References (10)
10 references, click to expand
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Article Info
Journal
Immunology
Abbr.
Immunology
ISSN
0019-2805
Published
1980-08-00
Pages
683-6
Language
English
Region
England
NLM ID
0374672
PMCID
PMC1458093
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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