The active centers of monoamine oxidase types "A" and "B": binding with (14C)-clorgyline and (14C)-deprenyl.

Journal of neural transmission ·Vol. 43 ·No. 3-4 ·1978-00-00 ·Pages 199-208

Youdim MB

Abstract

暂无摘要

MeSH Terms

Animals Binding Sites Brain/enzymology Cattle Clorgyline/metabolism Flavoproteins/metabolism Mitochondria, Liver/enzymology Monoamine Oxidase/metabolism Monoamine Oxidase Inhibitors/metabolism Phenylhydrazines/pharmacology Selegiline/metabolism Spectrum Analysis Substrate Specificity

Chemicals

Flavoproteins Monoamine Oxidase Inhibitors Phenylhydrazines Selegiline Monoamine Oxidase Clorgyline

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Youdim M B

References (20)

20 references, click to expand

Mitochondrial monoamine oxidase. Mechanism of inhibition by phenylhydrazine and by aralkylhydrazines. Role of enzymatic oxidation.
J Biol Chem. 1974 Apr 25;249(8):2373-80 PMID: 4822496
Deprenyl in Parkinson's disease.
Lancet. 1977 Oct 15;2(8042):791-5 PMID: 71602
Monoamine oxidase A and B: a useful concept?
Biochem Pharmacol. 1978 Jan 1;27(1):97-101 PMID: 619909
Implications of combined treatment with 'Madopar' and L-deprenil in Parkinson's disease. A long-term study.
Lancet. 1977 Feb 26;1(8009):439-43 PMID: 65560
The covalently-bound flavin of hepatic monoamine oxidase. 1. Isolation and sequence of a flavin peptide and evidence for binding at the 8alpha position.
Eur J Biochem. 1971 Dec;24(2):321-7 PMID: 4333601
Multiple forms of monoamine oxidase: fact and artefact.
Life Sci. 1976 Aug 15;19(4):467-77 PMID: 8682
Deprenyl administration in man: a selective monoamine oxidase B inhibitor without the 'cheese effect'.
Psychopharmacology (Berl). 1978 Apr 14;57(1):33-8 PMID: 96466
Some observations upon a new inhibitor of monoamine oxidase in brain tissue.
Biochem Pharmacol. 1968 Jul;17(7):1285-97 PMID: 5659776
Human liver mitochondrial monoamine oxidase. 3. Kinetic studies concerning time-dependent inhibitions.
Biochemistry. 1969 Oct;8(10):3963-72 PMID: 5346379
Some properties of monoamine oxidase.
Adv Biochem Psychopharmacol. 1972;5:11-24 PMID: 5054202
The prosthetic groups of pig brain mitochondrial monoamine oxidase.
Biochim Biophys Acta. 1968 Jul 9;159(3):451-9 PMID: 5657868
Mitochondrial monoamine oxidase. Inactivation by pargyline. Adduct formation.
J Biol Chem. 1974 Apr 25;249(8):2381-4 PMID: 4822497
Mitochondrial monoamine oxidase. II. Action of various inhibitors for the bovine kidney enzyme. Catalytic mechanism.
J Biol Chem. 1968 Oct 25;243(20):5234-43 PMID: 5702045
Some puzzling pharmacological effects of monoamine oxidase inhibitors.
Adv Biochem Psychopharmacol. 1972;5:393-408 PMID: 5066229
Monoamine oxidase: multiple forms and selective inhibitors.
Biochem J. 1971 Feb;121(3):34P-36P PMID: 4399166
8alpha-substituted flavins of biological importance: an updating.
FEBS Lett. 1976 May 1;64(2):255-65 PMID: 776685
The binding of (14C)phenethylhydrazine to rat liver monoamine oxidase.
Biochem Pharmacol. 1975 Mar 15;24(6):703-6 PMID: 1125071
Monoamine oxidase activity during (--)-deprenil therapy: human brain post-mortem studies.
Adv Biochem Psychopharmacol. 1978;19:377-82 PMID: 696465
The covalently-bound flavin of hepatic monoamine oxidase. 2. Identification and properties of cysteinyl riboflavin.
Eur J Biochem. 1971 Dec;24(2):328-31 PMID: 4333602
The potentiation of the anti akinetic effect after L-dopa treatment by an inhibitor of MAO-B, Deprenil.
J Neural Transm. 1975;36(3-4):303-26 PMID: 1172524

Article Info

Journal

Journal of neural transmission

Abbr.

J Neural Transm

DOI

10.1007/BF01246956

Published

1978-00-00

Pages

199-208

Language

English

Region

Austria

NLM ID

0337042

Subset

External Links

PubMed source DOI: 10.1007/BF01246956

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The active centers of monoamine oxidase types "A" and "B": binding with (14C)-clorgyline and (14C)-deprenyl.

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