Home LiteratureArticle Details

PMID: 7470751 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Antagonist discrimination between ganglionic and ileal muscarinic receptors.

British journal of pharmacology ·Vol. 71 ·No. 2 ·1980-00-00 ·Pages 362-4

Brown DA, Forward A, Marsh S

Abstract

The effects of four antagonists on the depolarization of isolated superior cervical ganglia and the contraction of isolated ileal segments of the rat were compared. pA2 values estimated from Schild plots indicated significantly higher affinities of stercuronium (x100) and pirenzepine (x23) and a significantly lower affinity of 4-diphenylacetoxy-N-methylpiperidine methiodide (x0.39) for the ganglion than for the ileum. The affinities of N-methylscopolamine for the two tissues were not significantly different. It is concluded that the two types of muscarinic receptor are not identical.

MeSH Terms

Animals Ganglia, Sympathetic/metabolism Ileum/metabolism In Vitro Techniques Muscarine/pharmacology Organ Specificity Parasympatholytics/pharmacology Rats Receptors, Cholinergic/drug effects Receptors, Muscarinic/drug effects

Chemicals

Parasympatholytics Receptors, Cholinergic Receptors, Muscarinic Muscarine

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Brown D A

Forward A

Marsh S

References (7)

7 references, click to expand

A comparison of affinity constants for muscarine-sensitive acetylcholine receptors in guinea-pig atrial pacemaker cells at 29 degrees C and in ileum at 29 degrees C and 37 degrees C.
Br J Pharmacol. 1976 Dec;58(4):613-20 PMID: 1000135
Axonal GABA-receptors in mammalian peripheral nerve trunks.
Brain Res. 1978 Nov 3;156(1):187-91 PMID: 212161
pA2 and receptor differentiation: a statistical analysis of competitive antagonism.
Life Sci. 1979 Aug 20;25(8):637-54 PMID: 388133
Pirenzepine distinguishes between different subclasses of muscarinic receptors.
Nature. 1980 Jan 3;283(5742):90-2 PMID: 7350532
Three types of muscarinic receptors? [proceedings].
Br J Pharmacol. 1980 Jan;68(1):141P-142P PMID: 7357156
The selective antimuscarinic action of stercuronium.
Br J Pharmacol. 1980 Oct;70(2):313-21 PMID: 6893558
Some quantitative uses of drug antagonists.
Br J Pharmacol Chemother. 1959 Mar;14(1):48-58 PMID: 13651579

Article Info

Journal

British journal of pharmacology

Abbr.

Br J Pharmacol

ISSN

0007-1188

DOI

10.1111/j.1476-5381.1980.tb10948.x

Published

1980-00-00

Pages

362-4

Language

English

Region

England

NLM ID

7502536

PMCID

PMC2044477

Subset

External Links

PubMed source DOI: 10.1111/j.1476-5381.1980.tb10948.x PMC Full Text View journal details

Analysis Services

Antagonist discrimination between ganglionic and ileal muscarinic receptors.

Contact

WeChat Official Account