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PMID: 7471514 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Circulating antigens, immune complexes and C3d levels in human schistosomiasis: relationship with Schistosoma mansoni egg output.

Clinical and experimental immunology ·Vol. 42 ·No. 2 ·1980-11-00 ·Pages 219-25

Santoro F, Prata A, Castro CN, Capron A

Abstract

Circulating schistosome antigens (CSA), circulating immune complexes (CIC) and C3 breakdown product - C3d - were investigated in human schistosomiasis in comparison to the S. mansoni egg count. A close relationship was observed between the mean number of eggs/g of stool and the detection of CSA (evaluated by the radioimmunoprecipitation-PEG assay - Ripega), CIC (Clq-binding test) and C3d levels (quantitated by radial immunodiffusion). All the patients with more than 500 S. mansoni eggs/g of stool also presented antigen '4', specific of the genus Schistosoma, in the serum. A significant correlation was noticed between levels of CSA and CIC. This suggests the involvement of several schistosome antigens in the detected CIC. No relationship was noted between CIC and C3d levels. In contrast, there was a highly significant correlation between levels of CSA and C3d. The interaction between certain schistosome antigens and the complement system is discussed.

MeSH Terms
Adolescent Adult Antigen-Antibody Complex/analysis Antigens/analysis Complement C3/analysis Feces/parasitology Humans Male Parasite Egg Count Schistosoma mansoni/immunology,isolation & purification Schistosomiasis/immunology,parasitology
Chemicals
Antigen-Antibody Complex Antigens Complement C3
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Santoro F
Prata A
Castro C N
Capron A
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29 references, click to expand
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Article Info
Journal
Clinical and experimental immunology
Abbr.
Clin Exp Immunol
ISSN
0009-9104
Published
1980-11-00
Pages
219-25
Language
English
Region
England
NLM ID
0057202
PMCID
PMC1537099
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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