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PMID: 7473681 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Potentiation of the effects of chlorhexidine diacetate and cetylpyridinium chloride on mycobacteria by ethambutol.

Journal of medical microbiology ·Vol. 43 ·No. 6 ·1995-12-00 ·Pages 458-60

Broadley SJ, Jenkins PA, Furr JR, Russell AD

Abstract

Ethambutol enhanced the effects of chlorhexidine diacetate and cetylpyridinium chloride against Mycobacterium avium, M. bovis BCG, M. fortuitum and M. phlei. The findings show that it is possible to increase the susceptibility of mycobacteria to agents that normally exhibit poor activity against these organisms because of their reduced cellular penetration.

MeSH Terms

Anti-Infective Agents, Local/pharmacology Antitubercular Agents/pharmacology Cetylpyridinium/pharmacology Chlorhexidine/pharmacology Colony Count, Microbial Drug Combinations Drug Interactions Drug Synergism Ethambutol/pharmacology Microbial Sensitivity Tests Mycobacterium/drug effects,physiology Mycobacterium avium/drug effects Mycobacterium bovis/drug effects Nontuberculous Mycobacteria/drug effects

Chemicals

Anti-Infective Agents, Local Antitubercular Agents Drug Combinations Ethambutol Cetylpyridinium Chlorhexidine

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Broadley S J

Welsh School of Pharmacy, University of Wales, Cardiff.

Jenkins P A

Furr J R

Russell A D

Article Info

Journal

Journal of medical microbiology

Abbr.

J Med Microbiol

ISSN

0022-2615

DOI

10.1099/00222615-43-6-458

Published

1995-12-00

Pages

458-60

Language

English

Region

England

NLM ID

0224131

Subset

External Links

PubMed source DOI: 10.1099/00222615-43-6-458 View journal details

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Potentiation of the effects of chlorhexidine diacetate and cetylpyridinium chloride on mycobacteria by ethambutol.

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