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PMID: 7479775 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Genes that control a temperature-compensated ultradian clock in Caenorhabditis elegans.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 92 ·No. 22 ·1995-10-24 ·Pages 10317-21

Iwasaki K, Liu DW, Thomas JH

Abstract

Substantial progress has been made in understanding the genetic basis of temperature-compensated circadian clocks. Ultradian rhythms, with a period shorter than 24 h, are at least as widespread as circadian rhythms. We have initiated genetic analysis of defecation behavior, which is controlled by an ultradian clock in Caenorhabditis elegans. The defecation motor program is activated every 45 sec, and this rhythm is temperature compensated. We describe mutations in 12 genes that either shorten or lengthen the cycle period. We find that most of these mutations also disrupt temperature compensation, suggesting that this process is an integral part of the clock. These genes open the way for molecular genetic dissection of this ultradian clock.

MeSH Terms
Activity Cycles/genetics Animals Caenorhabditis elegans/genetics,physiology Defecation Motor Activity Movement Mutagenesis Mutation Regression Analysis Temperature
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Iwasaki K
Department of Genetics, University of Washington, Seattle 98195, USA.
Liu D W
Thomas J H
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.92.22.10317
Published
1995-10-24
Pages
10317-21
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC40787
Subset
IM
Grants
NINDS NIH HHS · R01-NS30187 · United States
External Links
PubMed source DOI: 10.1073/pnas.92.22.10317 PMC Full Text View journal details
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