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PMID: 7480172 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

Multidrug resistance plasmid pSK108 from coagulase-negative staphylococci; relationships to Staphylococcus aureus qacC plasmids.

Plasmid ·Vol. 34 ·No. 1 ·1995-07-00 ·Pages 62-7

Leelaporn A, Firth N, Paulsen IT, Hettiaratchi A, Skurray RA

Abstract

The 2.4-kb Staphylococcus epidermidis plasmid, pSK108, encodes a qacC multidrug resistance determinant. Sequence analysis has revealed that pSK108 is a member of the pC194 family of rolling circle replicating plasmids and suggests that the DNA segment containing qacC, which is bounded by the replication nick site and the minus origin palA, represents a resistance gene cassette that has undergone horizontal genetic exchange.

MeSH Terms
Amino Acid Sequence Antiporters Bacterial Proteins/genetics Base Sequence Carrier Proteins/genetics Coagulase/metabolism DNA, Bacterial/genetics Drug Resistance, Multiple/genetics Escherichia coli Proteins Genes, Bacterial Membrane Proteins/genetics Molecular Sequence Data Plasmids/genetics Staphylococcus aureus/genetics Staphylococcus epidermidis/drug effects,enzymology,genetics
Chemicals
Antiporters Bacterial Proteins Carrier Proteins Coagulase DNA, Bacterial Escherichia coli Proteins Membrane Proteins EmrE protein, E coli
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Leelaporn A
School of Biological Sciences, University of Sydney, New South Wales, Australia.
Firth N
Paulsen I T
Hettiaratchi A
Skurray R A
Article Info
Journal
Plasmid
Abbr.
Plasmid
ISSN
0147-619X
DOI
10.1006/plas.1995.1034
Published
1995-07-00
Pages
62-7
Language
English
Region
United States
NLM ID
7802221
Subset
IM
Databases
GENBANK
U15783
External Links
PubMed source DOI: 10.1006/plas.1995.1034 View journal details
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